General Structure Information
| PDB ID | 3s5l |
| HGNC Gene Label(s) | HLA-DRA |
| Structure Name | crystal structure of cd4 mutant bound to hla-dr1 |
| Resolution | 2.1Å |
| Reference | AUTH X.X.WANG,Y.LI,Y.YIN,M.MO,Q.WANG,W.GAO,L.WANG,R.A.MARIUZZATITL AFFINITY MATURATION OF HUMAN CD4 BY YEAST SURFACE DISPLAYTITL 2 AND CRYSTAL STRUCTURE OF A CD4-HLA-DR1 COMPLEX.REF PROC.NATL.ACAD.SCI.USA V. 108 15960 2011REFN ISSN 0027-8424PMID 21900604DOI 10.1073/PNAS.1109438108 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 178 |
| Number Of SNVs | 29 |
| Number Of Permutations | 15530 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.044 |
| p-value | 0.42 |
COSMIC
| Number Of Residues | 178 |
| Number Of SNVs | 4 |
| Number Of Permutations | 285 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.167 |
| p-value | 0.931 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.194 |
| p-value | 0.775 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
