General Structure Information
| PDB ID | 2ax4 |
| HGNC Gene Label(s) | PAPSS2 |
| Structure Name | crystal structure of the kinase domain of human 3- phosphoadenosine 5-phosphosulphate synthetase 2 |
| Resolution | 2.5Å |
| Reference | AUTH W.M.RABEH,L.NEDYALKOVA,S.ISMAIL,H.PARK,AUTH 2 C.ARROWSMITH,A.EDWARDS,M.SUNDSTROM,J.WEIGELT,AUTH 3 A.BOCHKAREVTITL CRYSTAL STRUCTURE OF THE KINASE DOMAIN OF PAPSS 2REF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 195 |
| Number Of SNVs | 41 |
| Number Of Permutations | 16131 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.32 |
| p-value | 0.015 |
COSMIC
| Number Of Residues | 195 |
| Number Of SNVs | 3 |
| Number Of Permutations | 77 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.667 |
| p-value | 0.146 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.442 |
| p-value | 0.296 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
