General Structure Information
| PDB ID | 4jnl |
| HGNC Gene Label(s) | PLAU |
| Structure Name | crystal structure of upa in complex with its inhibitor 4- bromobenzylamine at ph 7.4 |
| Resolution | 2.0Å |
| Reference | AUTH X.ZHANG,L.JIANG,B.ZHAO,C.YUAN,M.HUANGTITL HALOGEN BONDS IN THE DESIGN OF SERINE PROTEASE INHIBITORSREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 227 |
| Number Of SNVs | 60 |
| Number Of Permutations | 19635 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.087 |
| p-value | 0.801 |
COSMIC
| Number Of Residues | 227 |
| Number Of SNVs | 3 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | -0.253 |
| p-value | 0.828 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
