Assessment of Structural Intolerance and Durability
General Structure Information 2bec CHP2 crystal structure of chp2 in complex with its binding region in nhe1 and insights into the mechanism of ph regulation 2.7Å AUTH Y.BEN AMMAR,S.TAKEDA,T.HISAMITSU,H.MORI,AUTH 2 S.WAKABAYASHITITL CRYSTAL STRUCTURE OF CHP2 COMPLEXED WITHTITL 2 NHE1-CYTOSOLIC REGION AND AN IMPLICATION FOR PHTITL 3 REGULATIONREF EMBO J. V. 25 2315 2006REFN ISSN 0261-4189PMID […]
General Structure Information 2q3e UGDH structure of human udp-glucose dehydrogenase complexed with nadh and udp-glucose 2.0Å AUTH S.EGGER,A.CHAIKUAD,K.L.KAVANAGH,U.OPPERMANN,B.NIDETZKYTITL STRUCTURE AND MECHANISM OF HUMAN UDP-GLUCOSETITL 2 6-DEHYDROGENASE.REF J.BIOL.CHEM. V. 286 23877 2011REFN ISSN 0021-9258PMID 21502315DOI 10.1074/JBC.M111.234682 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3p23 ERN1 crystal structure of the human kinase and rnase domains in complex with adp 2.7Å AUTH M.M.ALI,T.BAGRATUNI,E.L.DAVENPORT,P.R.NOWAK,AUTH 2 M.C.SILVA-SANTISTEBAN,A.HARDCASTLE,C.MCANDREWS,M.G.ROWLANDS,AUTH 3 G.J.MORGAN,W.AHERNE,I.COLLINS,F.E.DAVIES,L.H.PEARLTITL STRUCTURE OF THE IRE1 AUTOPHOSPHORYLATION COMPLEX ANDTITL 2 IMPLICATIONS FOR THE UNFOLDED PROTEIN RESPONSE.REF EMBO J. V. 30 894 2011REFN ISSN 0261-4189PMID 21317875DOI 10.1038/EMBOJ.2011.18 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 1ohc CDC14B structure of the proline directed phosphatase cdc14 2.5Å AUTH C.H.GRAY,V.M.GOOD,N.K.TONKS,D.BARFORDTITL THE STRUCTURE OF THE CELL CYCLE PROTEIN CDC14TITL 2 REVEALS A PROLINE-DIRECTED PROTEIN PHOSPHATASEREF EMBO J. V. 22 3524 2003REFN ISSN 0261-4189PMID 12853468DOI 10.1093/EMBOJ/CDG348 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4j5w NR1I2 crystal structure of the apo-pxr/rxralpha lbd heterotetramer complex 2.8Å AUTH B.D.WALLACE,L.BETTS,G.TALMAGE,R.M.POLLET,N.S.HOLMAN,AUTH 2 M.R.REDINBOTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE HUMAN NUCLEARTITL 2 XENOBIOTIC RECEPTOR PXR IN COMPLEX WITH RXRALPHA.REF J.MOL.BIOL. V. 425 2561 2013REFN ISSN 0022-2836PMID 23602807DOI 10.1016/J.JMB.2013.04.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2dkx SPDEF solution structure of the sam_pnt-domain of ets transcription factor pdef (prostate ets) -1.0Å AUTH A.K.GORONCY,M.SATO,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SAM_PNT-DOMAIN OF ETSTITL 2 TRANSCRIPTION FACTOR PDEF (PROSTATE ETS)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4jxm RRP9 crystal structure of rrp9 wd40 repeats 1.92Å AUTH X.WU,W.TEMPEL,C.XU,M.EL BAKKOURI,H.HE,Y.LI,C.BOUNTRA,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,J.MIN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF RRP9 WD40 REPEATSREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2e9k MICAL2 solution structure of the ch domain from human mical-2 -1.0Å AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN FROM HUMANTITL 2 MICAL-2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2yst PCDH7 solution structure of the third cadherin domain from human protocadherin 7 -1.0Å AUTH K.SEIMIYA,M.YOSHIDA,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD CADHERIN DOMAINTITL 2 FROM HUMAN PROTOCADHERIN 7REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b7l FLNB crystal structure of human filamin b actin binding domain with 1st filamin repeat 2.05Å AUTH G.M.SAWYER,A.J.SUTHERLAND-SMITHTITL CRYSTAL STRUCTURE OF THE FILAMIN N-TERMINAL REGION REVEALSTITL 2 A HINGE BETWEEN THE ACTIN BINDING AND FIRST REPEAT DOMAINSREF J.MOL.BIOL. V. 424 240 2012REFN ISSN 0022-2836PMID 23036857DOI 10.1016/J.JMB.2012.09.016 Variant Set Distributions Ripley’s K Analysis […]