General Structure Information
| PDB ID | 4b7l |
| HGNC Gene Label(s) | FLNB |
| Structure Name | crystal structure of human filamin b actin binding domain with 1st filamin repeat |
| Resolution | 2.05Å |
| Reference | AUTH G.M.SAWYER,A.J.SUTHERLAND-SMITHTITL CRYSTAL STRUCTURE OF THE FILAMIN N-TERMINAL REGION REVEALSTITL 2 A HINGE BETWEEN THE ACTIN BINDING AND FIRST REPEAT DOMAINSREF J.MOL.BIOL. V. 424 240 2012REFN ISSN 0022-2836PMID 23036857DOI 10.1016/J.JMB.2012.09.016 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 328 |
| Number Of SNVs | 54 |
| Number Of Permutations | 51116 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.109 |
| p-value | 0.021 |
ClinVar
| Number Of Residues | 328 |
| Number Of SNVs | 13 |
| Number Of Permutations | 13163 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.821 |
| p-value | 0.0 |
COSMIC
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of ClinVar SNVs | 13 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.67 |
| p-value | 0.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.324 |
| p-value | 0.101 |