Assessment of Structural Intolerance and Durability
General Structure Information 2qg1 MPDZ crystal structure of the 11th pdz domain of mpdz (mupp1) 1.4Å AUTH E.PAPAGRIGORIOU,E.SALAH,C.PHILLIPS,P.SAVITSKY,AUTH 2 P.BOISGUERIN,H.OSCHKINAT,C.GILEADI,X.YANG,AUTH 3 J.M.ELKINS,E.UGOCHUKWU,G.BUNKOCZI,J.UPPENBERG,AUTH 4 D.DOYLETITL CRYSTAL STRUCTURE OF THE 11TH PDZ DOMAIN OF MPDZTITL 2 (MUPP1).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3t6a BCAR3 structure of the c-terminal domain of bcar3 2.4Å AUTH P.D.MACE,Y.WALLEZ,M.K.DOBACZEWSKA,J.J.LEE,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL NSP-CAS PROTEIN STRUCTURES REVEAL A PROMISCUOUS INTERACTIONTITL 2 MODULE IN CELL SIGNALING.REF NAT.STRUCT.MOL.BIOL. V. 18 1381 2011REFN ISSN 1545-9993PMID 22081014DOI 10.1038/NSMB.2152 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m16 PSIP1 p75/ledgf pwwp domain -1.0Å AUTH J.O.EIDAHL,B.L.CROWE,J.A.NORTH,C.J.MCKEE,N.SHKRIABAI,L.FENG,AUTH 2 M.PLUMB,R.L.GRAHAM,R.J.GORELICK,S.HESS,M.G.POIRIER,AUTH 3 M.P.FOSTER,M.KVARATSKHELIATITL STRUCTURAL BASIS FOR HIGH-AFFINITY BINDING OF LEDGF PWWP TOTITL 2 MONONUCLEOSOMES.REF NUCLEIC ACIDS RES. V. 41 3924 2013REFN ISSN 0305-1048PMID 23396443DOI 10.1093/NAR/GKT074 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1yck PGLYRP1 crystal structure of human peptidoglycan recognition protein (pgrp-s) 1.7Å AUTH R.GUAN,Q.WANG,E.J.SUNDBERG,R.A.MARIUZZATITL CRYSTAL STRUCTURE OF HUMAN PEPTIDOGLYCANTITL 2 RECOGNITION PROTEIN S (PGRP-S) AT 1.70 ATITL 3 RESOLUTION.REF J.MOL.BIOL. V. 347 683 2005REFN ISSN 0022-2836PMID 15769462DOI 10.1016/J.JMB.2005.01.070 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dlo BAI3 crystal structure of the gain and hormr domains of brain angiogenesis inhibitor 3 (bai3) 2.3Å AUTH D.ARAC,A.A.BOUCARD,M.F.BOLLIGER,J.NGUYEN,S.M.SOLTIS,AUTH 2 T.C.SUDHOF,A.T.BRUNGERTITL A NOVEL EVOLUTIONARILY CONSERVED DOMAIN OF CELL-ADHESIONTITL 2 GPCRS MEDIATES AUTOPROTEOLYSIS.REF EMBO J. V. 31 1364 2012REFN ISSN 0261-4189PMID 22333914DOI 10.1038/EMBOJ.2012.26 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2fyt PRMT3 human hmt1 hnrnp methyltransferase-like 3 (s. cerevisiae) protein 2.0Å AUTH H.WU,J.R.MIN,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNPTITL 2 METHYLTRANSFERASE-LIKE 3 IN COMPLEX WITH SAH.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1t0l IDH1 crystal structure of human cytosolic nadp(+)-dependent isocitrate dehydrogenase in complex with nadp, isocitrate, and calcium(2+) 2.41Å AUTH X.XU,J.ZHAO,Z.XU,B.PENG,Q.HUANG,E.ARNOLD,J.DINGTITL STRUCTURES OF HUMAN CYTOSOLIC NADP-DEPENDENTTITL 2 ISOCITRATE DEHYDROGENASE REVEAL A NOVELTITL 3 SELF-REGULATORY MECHANISM OF ACTIVITYREF J.BIOL.CHEM. V. 279 33946 2004REFN ISSN 0021-9258PMID 15173171DOI 10.1074/JBC.M404298200 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2clp AKR7A3 crystal structure of human aflatoxin b1 aldehyde reductase member 3 3.0Å AUTH J.E.DEBRECZENI,C.JOHANSSON,K.KAVANAGH,A.TURNBULL,AUTH 2 E.PAPAGRIGORIOU,F.VON DELFT,A.EDWARDS,C.ARROWSMITH,AUTH 3 J.WEIGELT,M.SUNDSTROM,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN AFLATOXIN B1 ALDEHYDE REDUCTASETITL 2 MEMBER 3REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1fyx TLR2 crystal structure of p681h mutant of tir domain of human tlr2 2.8Å AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2d9w DOK2 solution structure of the ph domain of docking protein 2 from human -1.0Å AUTH H.LI,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE PH DOMAIN OF DOCKINGTITL 2 PROTEIN 2 FROM HUMANREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants