General Structure Information
| PDB ID | 1fyx |
| HGNC Gene Label(s) | TLR2 |
| Structure Name | crystal structure of p681h mutant of tir domain of human tlr2 |
| Resolution | 2.8Å |
| Reference | AUTH Y.XU,X.TAO,B.SHEN,T.HORNG,R.MEDZHITOV,J.L.MANLEY,L.TONGTITL STRUCTURAL BASIS FOR SIGNAL TRANSDUCTION BY THETITL 2 TOLL/INTERLEUKIN-1 RECEPTOR DOMAINS.REF NATURE V. 408 111 2000REFN ISSN 0028-0836PMID 11081518DOI 10.1038/35047056 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 145 |
| Number Of SNVs | 38 |
| Number Of Permutations | 13483 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.238 |
| p-value | 0.577 |
COSMIC
| Number Of Residues | 145 |
| Number Of SNVs | 3 |
| Number Of Permutations | 104 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.333 |
| p-value | 0.33 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | -0.43 |
| p-value | 0.316 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
