1OHC.A | CDC14B

General Structure Information

PDB ID	1ohc
HGNC Gene Label(s)	CDC14B
Structure Name	structure of the proline directed phosphatase cdc14
Resolution	2.5Å
Reference	AUTH C.H.GRAY,V.M.GOOD,N.K.TONKS,D.BARFORDTITL THE STRUCTURE OF THE CELL CYCLE PROTEIN CDC14TITL 2 REVEALS A PROLINE-DIRECTED PROTEIN PHOSPHATASEREF EMBO J. V. 22 3524 2003REFN ISSN 0261-4189PMID 12853468DOI 10.1093/EMBOJ/CDG348

Variant Set Distributions

ExAC Variants

Number Of Residues	339
Number Of SNVs	71
Number Of Permutations	14093
Optimal Distance Threshold	17.0
K Statistic	0.227
p-value	0.297

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:99381536		R>P	A:42	(36.94, -13.13, 44.94)
9:99381530		P>L	A:44	(34.06, -12.35, 51.29)
9:99381531		P>S	A:44	(34.06, -12.35, 51.29)
9:99381523		D>E	A:46	(37.30, -8.15, 48.63)
9:99327762		R>H	A:55	(17.86, 7.54, 53.56)
9:99327757		C>G	A:57	(24.65, 2.79, 50.47)
9:99327724		A>T	A:68	(18.36, -5.36, 58.82)
9:99327718		N>D	A:70	(17.50, -0.25, 60.02)
9:99327708		Y>C	A:73	(20.60, -4.70, 51.82)
9:99327706		F>V	A:74	(18.63, -2.02, 45.70)
9:99327693		N>S	A:78	(19.46, -9.77, 37.86)
9:99327694		N>D	A:78	(19.46, -9.77, 37.86)
9:99327676	rs141962545	N>D	A:84	(26.09, -8.54, 24.89)
9:99327130		Y>N	A:86	(32.31, -10.55, 20.83)
9:99327127	rs372463126	A>T	A:87	(32.97, -8.24, 24.83)
9:99327115		P>S	A:91	(27.75, 1.47, 29.28)
9:99327108		N>S	A:93	(20.62, 2.24, 28.19)
9:99327102		A>V	A:95	(16.67, 3.71, 30.01)
9:99327100		M>V	A:96	(18.52, 0.65, 31.93)
9:99327078		K>R	A:103	(14.27, 1.53, 41.94)
9:99327072	rs558364010	N>S	A:105	(13.89, 9.04, 43.52)
9:99327062		L>F	A:108	(14.55, 7.85, 49.05)
9:99327060		K>R	A:109	(9.31, 9.25, 47.63)
9:99325064	rs150380925	I>V	A:111	(5.78, 6.22, 54.23)
9:99325057	rs562014357	M>T	A:113	(11.81, 2.37, 53.46)
9:99325019		Q>E	A:126	(34.99, -7.38, 37.63)
9:99324994		F>C	A:134	(27.02, 4.17, 34.89)
9:99314147		Y>C	A:143	(18.14, 13.17, 40.00)
9:99314145		L>M	A:144	(22.57, 14.29, 43.86)
9:99314142	COSM1555534 COSM1555533	G>R	A:145	(25.10, 18.03, 42.61)
9:99314091		Y>H	A:162	(35.35, 0.27, 39.85)
9:99304173	rs371719363	D>N	A:167	(35.05, -2.37, 22.04)
9:99304157		S>N	A:172	(41.73, -6.53, 20.71)
9:99304158		S>G	A:172	(41.73, -6.53, 20.71)
9:99304151		N>S	A:174	(41.73, 0.29, 20.55)
9:99304134		L>F	A:180	(35.60, 10.18, 35.17)
9:99304119		A>S	A:185	(29.08, 12.91, 29.67)
9:99304111		K>N	A:187	(27.40, 17.43, 34.08)
9:99304113		K>E	A:187	(27.40, 17.43, 34.08)
9:99301421	rs369663439	A>V	A:189	(24.23, 16.32, 28.75)
9:99301418		M>K	A:190	(22.84, 17.83, 32.48)
9:99301394	rs568575642	N>S	A:198	(12.26, 16.69, 33.63)
9:99301395		N>D	A:198	(12.26, 16.69, 33.63)
9:99301387	rs375684489	F>L	A:200	(13.53, 10.13, 28.71)
9:99296824		K>E	A:210	(12.18, -2.63, 20.30)
9:99296814		N>S	A:213	(9.82, -0.75, 16.20)
9:99296815		N>H	A:213	(9.82, -0.75, 16.20)
9:99296802		N>S	A:217	(18.61, 5.64, 19.26)
9:99296797	rs201965822	I>V	A:219	(22.32, 10.68, 19.76)
9:99296792	rs143071893	I>M	A:220	(21.52, 15.23, 19.87)
9:99296784		R>L	A:223	(20.48, 18.60, 14.96)
9:99296430		Q>R	A:242	(15.27, -6.06, 6.27)
9:99296431	rs188916907	Q>K	A:242	(15.27, -6.06, 6.27)
9:99296298	rs199974150 COSM3930223 COSM3930222 COSM3930221 COSM3930219 COSM3930220	A>V	A:286	(34.56, 1.53, 4.48)
9:99296286	rs146918567	T>I	A:290	(38.20, 5.38, 9.20)
9:99296278	rs369779976	D>N	A:293	(39.63, 14.44, 6.71)
9:99296269		V>I	A:296	(34.65, 14.57, 8.36)
9:99296250	rs16911114	I>T	A:302	(25.48, 17.98, 5.37)
9:99296247		C>S	A:303	(25.14, 18.85, 9.60)
9:99286001		L>R	A:318	(26.24, 1.09, 15.83)
9:99285995		R>H	A:320	(29.81, 2.95, 9.00)
9:99285996	COSM329238	R>C	A:320	(29.81, 2.95, 9.00)
9:99285986		T>S	A:323	(32.21, 7.75, 14.11)
9:99285971		Y>C	A:328	(27.95, 18.23, 15.24)
9:99285969	rs149857428	I>V	A:329	(29.47, 16.15, 19.54)
9:99285966		M>V	A:330	(34.36, 16.20, 19.23)
9:99285962		K>T	A:331	(33.40, 21.10, 15.47)
9:99285954		R>G	A:334	(36.22, 22.35, 23.14)
9:99285939		E>K	A:339	(33.56, 13.25, 27.36)
9:99285936	rs139855966	T>A	A:340	(31.61, 11.76, 22.71)
9:99285932	rs16911075	I>T	A:341	(32.70, 7.39, 22.77)
9:99285929	rs151098648	A>V	A:342	(30.06, 7.74, 26.22)
9:99285891		P>S	A:355	(39.51, 1.35, 14.24)
9:99285884		Q>R	A:357	(37.68, 3.70, 19.60)
9:99285692		N>D	A:366	(41.42, 19.14, 14.10)
9:99285664	COSM1111622 COSM1598577 COSM1598578	R>H	A:375	(32.56, 28.15, 18.38)
9:99285665	COSM199129 COSM3927898 COSM3927897 COSM3927895 COSM3927896	R>C	A:375	(32.56, 28.15, 18.38)
9:99285659		K>E	A:377	(32.93, 33.34, 12.41)
9:99285652		K>R	A:379	(31.06, 36.33, 15.49)
9:99285650	rs145918500	G>R	A:380	(30.54, 38.48, 15.60)

1OHC.A | CDC14B.

1OHC.A | CDC14B

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
9:99327763	COSM1200334	R>C	A:55	(17.86, 7.54, 53.56)
9:99285664	COSM1111622	R>H	A:375	(32.56, 28.15, 18.38)
9:99285665	COSM3927896	R>C	A:375	(32.56, 28.15, 18.38)