2E9K.A | MICAL2

General Structure Information

PDB ID	2e9k
HGNC Gene Label(s)	MICAL2
Structure Name	solution structure of the ch domain from human mical-2
Resolution	-1.0Å
Reference	AUTH T.TOMIZAWA,N.TOCHIO,S.KOSHIBA,S.WATANABE,T.HARADA,AUTH 2 T.KIGAWA,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE CH DOMAIN FROM HUMANTITL 2 MICAL-2REF TO BE PUBLISHEDREFN

Variant Set Distributions

ExAC Variants

Number Of Residues	114
Number Of SNVs	41
Number Of Permutations	9704
Optimal Distance Threshold	13.0
K Statistic	0.228
p-value	0.679

COSMIC

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Pathogenic Proximity Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:12246228		I>V	A:9	(-10.22, -11.76, 1.93)
11:12246239	rs551546075	S>R	A:12	(-6.99, -9.07, 4.32)
11:12246240	rs571399686	K>E	A:13	(-1.88, -6.18, 4.77)
11:12246264		Q>E	A:21	(-4.94, 5.37, 8.63)
11:12246277		Y>C	A:25	(-11.70, 10.78, 10.99)
11:12246282	rs373245185	H>Y	A:27	(-21.03, 10.35, 11.80)
11:12246291		V>I	A:30	(-14.00, 1.74, 7.07)
11:12246297		D>N	A:32	(-16.10, -3.29, 3.45)
11:12246304		T>I	A:34	(-16.99, -1.93, -1.79)
11:12246307		T>I	A:35	(-20.02, 0.54, 0.83)
11:12246309		S>T	A:36	(-16.66, 1.74, 2.93)
11:12246316	rs370855282 COSM1352050 COSM3444434 COSM3444435	R>H	A:38	(-22.13, 4.59, -1.23)
11:12246318		S>G	A:39	(-19.51, 9.02, 0.51)
11:12246347		H>Q	A:48	(-7.80, 15.85, 7.05)
11:12246348	rs140261770	R>C	A:49	(-5.13, 11.61, 10.50)
11:12246349		R>H	A:49	(-5.13, 11.61, 10.50)
11:12246354	rs138170636	R>W	A:51	(-0.27, 17.59, 3.60)
11:12246355	rs35387130	R>Q	A:51	(-0.27, 17.59, 3.60)
11:12247720	COSM3738903 COSM3738904	N>T	A:56	(-12.49, 20.56, 4.43)
11:12247728		S>A	A:59	(-17.20, 21.10, 4.75)
11:12247737		E>K	A:62	(-23.86, 12.97, 4.73)
11:12247743		D>N	A:64	(-22.32, 16.85, 0.07)
11:12247759		N>S	A:69	(-16.59, 11.51, -3.85)
11:12247770	rs146600661	F>I	A:73	(-11.85, 11.16, -6.67)
11:12247776		V>M	A:75	(-6.87, 16.83, -3.91)
11:12247780		A>V	A:76	(-5.34, 12.78, -5.67)
11:12247782	rs201389190	E>K	A:77	(-5.58, 14.09, -10.62)
11:12247785	rs574255304 COSM1352052	R>G	A:78	(-4.57, 19.50, -9.45)
11:12247786	rs144478365	R>Q	A:78	(-4.57, 19.50, -9.45)
11:12247789		E>G	A:79	(-1.10, 17.12, -4.93)
11:12247813	COSM1317381	T>M	A:87	(-17.18, 9.55, -12.15)
11:12247824		M>V	A:91	(-18.37, 5.94, -5.92)
11:12247838		Q>H	A:95	(-26.18, -0.43, -4.04)
11:12247849	rs200779809	K>R	A:99	(-13.76, -6.81, -3.57)
11:12247851	rs184076407	L>F	A:100	(-11.43, -6.57, -7.85)
11:12247857		M>V	A:102	(-12.53, 0.29, -4.71)
11:12247860	rs142377929	V>F	A:103	(-8.51, -3.39, -3.92)
11:12247863		M>V	A:104	(-7.59, -1.79, -8.90)
11:12247864		M>T	A:104	(-7.59, -1.79, -8.90)
11:12247865		M>I	A:104	(-7.59, -1.79, -8.90)
11:12247867		Y>F	A:105	(-8.18, 4.46, -6.79)
11:12247880		F>L	A:109	(-4.58, 6.63, -2.20)
11:12247884	rs112284613	E>K	A:111	(1.72, 2.14, -2.68)
11:12247887	rs146366739	L>I	A:112	(1.50, 7.51, -2.57)
11:12247893	COSM1675844 COSM1675845	R>W	A:114	(3.24, 0.53, 4.45)
11:12247897		G>D	A:115	(6.96, 3.91, 3.29)

2E9K.A | MICAL2.

2E9K.A | MICAL2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:12246310	COSM4166365	S>F	A:36	(-16.66, 1.74, 2.93)
11:12247893	COSM1675844	R>W	A:114	(3.24, 0.53, 4.45)
11:12247914	COSM1973347	V>M	A:121	(2.55, 4.67, 17.37)