General Structure Information
| PDB ID | 2lwi |
| HGNC Gene Label(s) | HRAS |
| Structure Name | solution structure of h-rast35s mutant protein in complex with kobe2601 |
| Resolution | -1.0Å |
| Reference | AUTH F.SHIMA,Y.YOSHIKAWA,M.YE,M.ARAKI,S.MATSUMOTO,J.LIAO,L.HU,AUTH 2 T.SUGIMOTO,Y.IJIRI,A.TAKEDA,Y.NISHIYAMA,C.SATO,S.MURAOKA,AUTH 3 A.TAMURA,T.OSODA,K.I.TSUDA,T.MIYAKAWA,H.FUKUNISHI,J.SHIMADA,AUTH 4 T.KUMASAKA,M.YAMAMOTO,T.KATAOKATITL IN SILICO DISCOVERY OF SMALL-MOLECULE RAS INHIBITORS THATTITL 2 DISPLAY ANTITUMOR ACTIVITY BY BLOCKING THE RAS-EFFECTORTITL 3 INTERACTION.REF PROC.NATL.ACAD.SCI.USA 2013REFN ESSN 1091-6490PMID 23630290DOI 10.1073/PNAS.1217730110 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 166 |
| Number Of SNVs | 27 |
| Number Of Permutations | 7240 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.071 |
| p-value | 0.589 |
ClinVar
| Number Of Residues | 166 |
| Number Of SNVs | 11 |
| Number Of Permutations | 2673 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.364 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 166 |
| Number Of SNVs | 9 |
| Number Of Permutations | 818 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.056 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.243 |
| p-value | 0.045 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 27 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.222 |
| p-value | 0.418 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
