Assessment of Structural Intolerance and Durability
General Structure Information 2jdf CRYGB human gamma-b crystallin 1.7Å AUTH H.EBERSBACH,E.FIEDLER,T.SCHEUERMANN,M.FIEDLER,AUTH 2 M.T.STUBBS,C.REIMANN,G.PROETZEL,R.RUDOLPH,U.FIEDLERTITL AFFILIN-NOVEL BINDING MOLECULES BASED ON HUMANTITL 2 GAMMA-B-CRYSTALLIN, AN ALL BETA-SHEET PROTEIN.REF J.MOL.BIOL. V. 372 172 2007REFN ISSN 0022-2836PMID 17628592DOI 10.1016/J.JMB.2007.06.045 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nll THRB retinoid x receptor-thyroid hormone receptor dna-binding domain heterodimer bound to thyroid response element dna 1.9Å AUTH F.RASTINEJAD,T.PERLMANN,R.M.EVANS,P.B.SIGLERTITL STRUCTURAL DETERMINANTS OF NUCLEAR RECEPTORTITL 2 ASSEMBLY ON DNA DIRECT REPEATS.REF NATURE V. 375 203 1995REFN ISSN 0028-0836PMID 7746322DOI 10.1038/375203A0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1g83 FYN crystal structure of fyn sh3-sh2 2.6Å AUTH S.T.AROLD,T.S.ULMER,T.D.MULHERN,J.M.WERNER,AUTH 2 J.E.LADBURY,I.D.CAMPBELL,M.E.NOBLETITL THE ROLE OF THE SRC HOMOLOGY 3-SRC HOMOLOGY 2TITL 2 INTERFACE IN THE REGULATION OF SRC KINASES.REF J.BIOL.CHEM. V. 276 17199 2001REFN ISSN 0021-9258PMID 11278857DOI 10.1074/JBC.M011185200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3q6n HSP90AA1 crystal structure of human mc-hsp90 in p21 space group 3.05Å AUTH C.C.LEE,T.W.LIN,T.P.KO,A.H.-J.WANGTITL THE HEXAMERIC STRUCTURES OF HUMAN HEAT SHOCK PROTEIN 90REF PLOS ONE V. 6 19961 2011REFN ESSN 1932-6203PMID 21647436DOI 10.1371/JOURNAL.PONE.0019961 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1hlg LIPF crystal structure of human gastric lipase 3.0Å AUTH A.ROUSSEL,S.CANAAN,M.P.EGLOFF,M.RIVIERE,L.DUPUIS,R.VERGER,AUTH 2 C.CAMBILLAUTITL CRYSTAL STRUCTURE OF HUMAN GASTRIC LIPASE AND MODEL OFTITL 2 LYSOSOMAL ACID LIPASE, TWO LIPOLYTIC ENZYMES OF MEDICALTITL 3 INTEREST.REF J.BIOL.CHEM. V. 274 16995 1999REFN ISSN 0021-9258PMID 10358049DOI 10.1074/JBC.274.24.16995 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2pfr NAT2 human n-acetyltransferase 2 1.92Å AUTH H.WU,W.TEMPEL,L.DOMBROVSKI,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,D.M.GRANT,AUTH 3 A.N.PLOTNIKOV,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN N-ACETYLTRANSFERASE 2 INTITL 2 COMPLEX WITH COAREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zbf ROS1 structure of human ros1 kinase domain in complex with crizotinib 2.2Å AUTH M.M.AWAD,R.KATAYAMA,M.MCTIGUE,W.LIU,Y.DENG,A.BROOUN,AUTH 2 L.FRIBOULET,D.HUANG,M.D.FALK,S.TIMOFEEVSKI,K.D.WILNER,AUTH 3 E.L.LOCKERMAN,T.M.KHAN,S.MAHMOOD,J.F.GAINOR,S.R.DIGUMARTHY,AUTH 4 J.R.STONE,M.MINO-KENUDSON,J.G.CHRISTENSEN,J.IAFRATE,AUTH 5 J.A.ENGELMAN,A.T.SHAWTITL ACQUIRED RESISTANCE TO CRIZOTINIB FROM A MUTATION INTITL 2 CD74-ROS1REF N.ENGL.J.MED. V. 368 2395 2013REFN ISSN 0028-4793PMID 23724914DOI 10.1056/NEJMOA1215530 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1z6c PROS1 solution structure of an egf pair (egf34) from vitamin k- dependent protein s -1.0Å AUTH T.DRAKENBERG,H.GHASRIANI,E.THULIN,A.MURANYI,AUTH 2 A.ANNILA,J.STENFLOTITL SOLUTION STRUCTURE OF THE CA(2+)-BINDING EGF3-4TITL 2 PAIR FROM VITAMIN K-DEPENDENT PROTEIN S:TITL 3 IDENTIFICATION OF AN UNUSUAL FOLD IN EGF3.REF BIOCHEMISTRY V. 44 8782 2005REFN ISSN 0006-2960PMID 15952784DOI 10.1021/BI050101F Variant Set […]
General Structure Information 1jlm ITGAM i-domain from integrin cr3, mn2+ bound 2.0Å AUTH J.O.LEE,L.A.BANKSTON,M.A.ARNAOUT,R.C.LIDDINGTONTITL TWO CONFORMATIONS OF THE INTEGRIN A-DOMAINTITL 2 (I-DOMAIN): A PATHWAY FOR ACTIVATION?REF STRUCTURE V. 3 1333 1995REFN ISSN 0969-2126PMID 8747460DOI 10.1016/S0969-2126(01)00271-4 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1pq2 CYP2C8 crystal structure of human drug metabolizing cytochrome p450 2c8 2.7Å AUTH G.A.SCHOCH,J.K.YANO,M.R.WESTER,K.J.GRIFFIN,AUTH 2 C.D.STOUT,E.F.JOHNSONTITL STRUCTURE OF HUMAN MICROSOMAL CYTOCHROME P450 2C8.TITL 2 EVIDENCE FOR A PERIPHERAL FATTY ACID BINDING SITEREF J.BIOL.CHEM. V. 279 9497 2004REFN ISSN 0021-9258PMID 14676196DOI 10.1074/JBC.M312516200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]