General Structure Information
| PDB ID | 3zbf |
| HGNC Gene Label(s) | ROS1 |
| Structure Name | structure of human ros1 kinase domain in complex with crizotinib |
| Resolution | 2.2Å |
| Reference | AUTH M.M.AWAD,R.KATAYAMA,M.MCTIGUE,W.LIU,Y.DENG,A.BROOUN,AUTH 2 L.FRIBOULET,D.HUANG,M.D.FALK,S.TIMOFEEVSKI,K.D.WILNER,AUTH 3 E.L.LOCKERMAN,T.M.KHAN,S.MAHMOOD,J.F.GAINOR,S.R.DIGUMARTHY,AUTH 4 J.R.STONE,M.MINO-KENUDSON,J.G.CHRISTENSEN,J.IAFRATE,AUTH 5 J.A.ENGELMAN,A.T.SHAWTITL ACQUIRED RESISTANCE TO CRIZOTINIB FROM A MUTATION INTITL 2 CD74-ROS1REF N.ENGL.J.MED. V. 368 2395 2013REFN ISSN 0028-4793PMID 23724914DOI 10.1056/NEJMOA1215530 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 282 |
| Number Of SNVs | 76 |
| Number Of Permutations | 13955 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.067 |
| p-value | 0.258 |
COSMIC
| Number Of Residues | 282 |
| Number Of SNVs | 5 |
| Number Of Permutations | 504 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.1 |
| p-value | 0.091 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.377 |
| p-value | 0.216 |