Assessment of Structural Intolerance and Durability
General Structure Information 1cjl CTSL crystal structure of a cysteine protease proform 2.2Å AUTH R.COULOMBE,P.GROCHULSKI,J.SIVARAMAN,R.MENARD,AUTH 2 J.S.MORT,M.CYGLERTITL STRUCTURE OF HUMAN PROCATHEPSIN L REVEALS THETITL 2 MOLECULAR BASIS OF INHIBITION BY THE PROSEGMENT.REF EMBO J. V. 15 5492 1996REFN ISSN 0261-4189PMID 8896443 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2h2r FCER2 crystal structure of the human cd23 lectin domain, apo form 1.5Å AUTH B.A.WURZBURG,S.S.TARCHEVSKAYA,T.S.JARDETZKYTITL STRUCTURAL CHANGES IN THE LECTIN DOMAIN OF CD23,TITL 2 THE LOW-AFFINITY IGE RECEPTOR, UPON CALCIUMTITL 3 BINDING.REF STRUCTURE V. 14 1049 2006REFN ISSN 0969-2126PMID 16765898DOI 10.1016/J.STR.2006.03.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 2v53 SPARC crystal structure of a sparc-collagen complex 3.2Å AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4dqy PARP1 structure of human parp-1 bound to a dna double strand break 3.25Å AUTH M.F.LANGELIER,J.L.PLANCK,S.ROY,J.M.PASCALTITL STRUCTURAL BASIS FOR DNA DAMAGE-DEPENDENTTITL 2 POLY(ADP-RIBOSYL)ATION BY HUMAN PARP-1.REF SCIENCE V. 336 728 2012REFN ISSN 0036-8075PMID 22582261DOI 10.1126/SCIENCE.1216338 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3uyq CA3 hca 3 1.7Å AUTH I.ELDER,Z.FISHER,P.J.LAIPIS,C.TU,R.MCKENNA,D.N.SILVERMANTITL STRUCTURAL AND KINETIC ANALYSIS OF PROTON SHUTTLE RESIDUESTITL 2 IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE III.REF PROTEINS V. 68 337 2007REFN ISSN 0887-3585PMID 17427958DOI 10.1002/PROT.21403 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1m9i ANXA6 crystal structure of phosphorylation-mimicking mutant t356d of annexin vi 2.65Å AUTH C.FREYE-MINKS,R.H.KRETSINGER,C.E.CREUTZTITL STRUCTURAL AND DYNAMIC CHANGES IN HUMAN ANNEXIN VITITL 2 INDUCED BY A PHOSPHORYLATION-MIMICKING MUTATION,TITL 3 T356DREF BIOCHEMISTRY V. 42 620 2003REFN ISSN 0006-2960PMID 12534274DOI 10.1021/BI026742H Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2fze ADH5 crystal structure of the binary complex of human glutathione-dependent formaldehyde dehydrogenase with adp- ribose 1.9Å AUTH P.C.SANGHANI,W.I.DAVIS,L.ZHAI,H.ROBINSONTITL STRUCTURE-FUNCTION RELATIONSHIPS IN HUMANTITL 2 GLUTATHIONE-DEPENDENT FORMALDEHYDE DEHYDROGENASE.TITL 3 ROLE OF GLU-67 AND ARG-368 IN THE CATALYTICTITL 4 MECHANISM.REF BIOCHEMISTRY V. 45 4819 2006REFN ISSN 0006-2960PMID 16605250DOI 10.1021/BI052554Q Variant Set Distributions Ripley’s K […]
General Structure Information 3ojy C8B crystal structure of human complement component c8 2.51Å AUTH L.L.LOVELACE,C.L.COOPER,J.M.SODETZ,L.LEBIODATITL STRUCTURE OF HUMAN C8 PROTEIN PROVIDES MECHANISTIC INSIGHTTITL 2 INTO MEMBRANE PORE FORMATION BY COMPLEMENT.REF J.BIOL.CHEM. V. 286 17585 2011REFN ISSN 0021-9258PMID 21454577DOI 10.1074/JBC.M111.219766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ojy C8A crystal structure of human complement component c8 2.51Å AUTH L.L.LOVELACE,C.L.COOPER,J.M.SODETZ,L.LEBIODATITL STRUCTURE OF HUMAN C8 PROTEIN PROVIDES MECHANISTIC INSIGHTTITL 2 INTO MEMBRANE PORE FORMATION BY COMPLEMENT.REF J.BIOL.CHEM. V. 286 17585 2011REFN ISSN 0021-9258PMID 21454577DOI 10.1074/JBC.M111.219766 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1lar PTPRF crystal structure of the tandem phosphatase domains of rptp lar 2.0Å AUTH H.J.NAM,F.POY,N.X.KRUEGER,H.SAITO,C.A.FREDERICKTITL CRYSTAL STRUCTURE OF THE TANDEM PHOSPHATASETITL 2 DOMAINS OF RPTP LAR.REF CELL(CAMBRIDGE,MASS.) V. 97 449 1999REFN ISSN 0092-8674PMID 10338209DOI 10.1016/S0092-8674(00)80755-2 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants