Assessment of Structural Intolerance and Durability
General Structure Information 4g1m ITGAV re-refinement of alpha v beta 3 structure 2.9Å AUTH X.DONG,L.Z.MI,J.ZHU,W.WANG,P.HU,B.H.LUO,T.A.SPRINGERTITL ALPHA V BETA 3 INTEGRIN CRYSTAL STRUCTURES AND THEIRTITL 2 FUNCTIONAL IMPLICATIONSREF BIOCHEMISTRY V. 51 8814 2012REFN ISSN 0006-2960PMID 23106217DOI 10.1021/BI300734N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ggf S100A9 crystal structure of mn2+ bound calprotectin 1.6Å AUTH S.M.DAMO,T.E.KEHL-FIE,N.SUGITANI,M.E.HOLT,S.RATHI,AUTH 2 W.J.MURPHY,Y.ZHANG,C.BETZ,L.HENCH,G.FRITZ,E.P.SKAAR,AUTH 3 W.J.CHAZINTITL MOLECULAR BASIS FOR MANGANESE SEQUESTRATION BY CALPROTECTINTITL 2 AND ROLES IN THE INNATE IMMUNE RESPONSE TO INVADINGTITL 3 BACTERIAL PATHOGENS.REF PROC.NATL.ACAD.SCI.USA V. 110 3841 2013REFN ISSN 0027-8424PMID 23431180DOI 10.1073/PNAS.1220341110 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4mqs CHRM2 structure of active human m2 muscarinic acetylcholine receptor bound to the agonist iperoxo 3.5Å AUTH A.C.KRUSE,A.M.RING,A.MANGLIK,J.HU,K.HU,K.EITEL,H.HUBNER,AUTH 2 E.PARDON,C.VALANT,P.M.SEXTON,A.CHRISTOPOULOS,C.C.FELDER,AUTH 3 P.GMEINER,J.STEYAERT,W.I.WEIS,K.C.GARCIA,J.WESS,B.K.KOBILKATITL ACTIVATION AND ALLOSTERIC MODULATION OF A MUSCARINICTITL 2 ACETYLCHOLINE RECEPTOR.REF NATURE V. 504 101 2013REFN ISSN 0028-0836PMID 24256733DOI 10.1038/NATURE12735 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1hk0 CRYGD human gamma-d crystallin structure at 1.25 a resolution 1.25Å AUTH A.K.BASAK,O.BATEMAN,C.SLINGSBY,A.PANDE,N.ASHERIE,AUTH 2 O.OGUN,G.BENEDEK,J.PANDETITL HIGH-RESOLUTION X-RAY CRYSTAL STRUCTURES OF HUMANTITL 2 GAMMAD CRYSTALLIN (1.25A) AND THE R58H MUTANTTITL 3 (1.15A) ASSOCIATED WITH ACULEIFORM CATARACTREF J.MOL.BIOL. V. 328 1137 2003REFN ISSN 0022-2836PMID 12729747DOI 10.1016/S0022-2836(03)00375-9 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 2xsn TH crystal structure of human tyrosine hydroxylase catalytic domain 2.68Å AUTH J.R.C.MUNIZ,C.D.O.COOPER,W.W.YUE,E.KRYSZTOFINSKA,AUTH 2 F.VON DELFT,S.KNAPP,O.GILEADI,C.H.ARROWSMITH,A.M.EDWARDS,AUTH 3 J.WEIGELT,C.BOUNTRA,K.L.KAVANAGH,U.OPPERMANNTITL CRYSTAL STRUCTURE OF HUMAN TYROSINE HYDROXYLASE CATALYTICTITL 2 DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ewu UMPS d312n mutant of human orotidyl-5-monophosphate decarboxylase in complex with 6-acetyl-ump, covalent adduct 1.6Å AUTH D.HEINRICH,U.DIEDERICHSEN,M.G.RUDOLPHTITL LYS314 IS A NUCLEOPHILE IN NON-CLASSICAL REACTIONS OFTITL 2 OROTIDINE-5-MONOPHOSPHATE DECARBOXYLASEREF CHEMISTRY V. 15 6619 2009REFN ISSN 0947-6539PMID 19472232DOI 10.1002/CHEM.200900397 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4elj RB1 crystal structure of the inactive retinoblastoma protein phosphorylated at t373 2.7Å AUTH J.R.BURKE,G.L.HURA,S.M.RUBINTITL STRUCTURES OF INACTIVE RETINOBLASTOMA PROTEIN REVEALTITL 2 MULTIPLE MECHANISMS FOR CELL CYCLE CONTROL.REF GENES DEV. V. 26 1156 2012REFN ISSN 0890-9369PMID 22569856DOI 10.1101/GAD.189837.112 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 1rrj TOP1 structural mechanisms of camptothecin resistance by mutations in human topoisomerase i 2.3Å AUTH J.E.CHRENCIK,B.L.STAKER,A.B.BURGIN,P.POURQUIER,AUTH 2 Y.POMMIER,L.STEWART,M.R.REDINBOTITL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY HUMANTITL 2 TOPOISOMERASE I MUTATIONSREF J.MOL.BIOL. V. 339 773 2004REFN ISSN 0022-2836PMID 15165849DOI 10.1016/J.JMB.2004.03.077 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k87 EPRS crystal structure of human prolyl-trna synthetase (substrate bound form) 2.3Å AUTH J.SON,E.H.LEE,M.PARK,J.H.KIM,J.KIM,S.KIM,Y.H.JEON,K.Y.HWANGTITL CONFORMATIONAL CHANGES IN HUMAN PROLYL-TRNA SYNTHETASE UPONTITL 2 BINDING OF THE SUBSTRATES PROLINE AND ATP AND THE INHIBITORTITL 3 HALOFUGINONEREF ACTA CRYSTALLOGR.,SECT.D V. 69 2136 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913020556 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]