General Structure Information
| PDB ID | 4k87 |
| HGNC Gene Label(s) | EPRS |
| Structure Name | crystal structure of human prolyl-trna synthetase (substrate bound form) |
| Resolution | 2.3Å |
| Reference | AUTH J.SON,E.H.LEE,M.PARK,J.H.KIM,J.KIM,S.KIM,Y.H.JEON,K.Y.HWANGTITL CONFORMATIONAL CHANGES IN HUMAN PROLYL-TRNA SYNTHETASE UPONTITL 2 BINDING OF THE SUBSTRATES PROLINE AND ATP AND THE INHIBITORTITL 3 HALOFUGINONEREF ACTA CRYSTALLOGR.,SECT.D V. 69 2136 2013REFN ISSN 0907-4449DOI 10.1107/S0907444913020556 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 490 |
| Number Of SNVs | 108 |
| Number Of Permutations | 66985 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.106 |
| p-value | 0.05 |
COSMIC
| Number Of Residues | 490 |
| Number Of SNVs | 5 |
| Number Of Permutations | 253 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.1 |
| p-value | 0.82 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 108 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.27 |
| p-value | 0.274 |