General Structure Information
| PDB ID | 2v53 |
| HGNC Gene Label(s) | SPARC |
| Structure Name | crystal structure of a sparc-collagen complex |
| Resolution | 3.2Å |
| Reference | AUTH E.HOHENESTER,T.SASAKI,C.GIUDICI,R.W.FARNDALE,AUTH 2 H.P.BACHINGERTITL STRUCTURAL BASIS OF SEQUENCE-SPECIFIC COLLAGENTITL 2 RECOGNITION BY SPARC.REF PROC.NATL.ACAD.SCI.USA V. 105 18273 2008REFN ISSN 0027-8424PMID 19011090DOI 10.1073/PNAS.0808452105 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 215 |
| Number Of SNVs | 54 |
| Number Of Permutations | 38432 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.227 |
| p-value | 0.39 |
COSMIC
| Number Of Residues | 215 |
| Number Of SNVs | 3 |
| Number Of Permutations | 265 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.561 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.278 |
| p-value | 0.944 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
