General Structure Information
| PDB ID | 2pfr |
| HGNC Gene Label(s) | NAT2 |
| Structure Name | human n-acetyltransferase 2 |
| Resolution | 1.92Å |
| Reference | AUTH H.WU,W.TEMPEL,L.DOMBROVSKI,P.LOPPNAU,J.WEIGELT,M.SUNDSTROM,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,D.M.GRANT,AUTH 3 A.N.PLOTNIKOV,STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL THE CRYSTAL STRUCTURE OF HUMAN N-ACETYLTRANSFERASE 2 INTITL 2 COMPLEX WITH COAREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 289 |
| Number Of SNVs | 102 |
| Number Of Permutations | 10868 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.012 |
| p-value | 0.322 |
COSMIC
| Number Of Residues | 289 |
| Number Of SNVs | 5 |
| Number Of Permutations | 416 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.2 |
| p-value | 0.184 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 102 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.095 |
| p-value | 0.168 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
