Assessment of Structural Intolerance and Durability
General Structure Information 2y1m CBL structure of native c-cbl 2.67Å AUTH H.DOU,L.BUETOW,A.HOCK,G.J.SIBBET,K.H.VOUSDEN,D.T.HUANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION AND PHOSPHORYLATION-TITL 2 DEPENDENT ACTIVATION OF C-CBL.REF NAT.STRUCT.MOL.BIOL. V. 19 184 2012REFN ISSN 1545-9993PMID 22266821DOI 10.1038/NSMB.2231 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rgh FLNA structure of filamin a immunoglobulin-like repeat 10 from homo sapiens 2.44Å AUTH R.C.PAGE,J.G.CLARK,S.MISRATITL STRUCTURE OF FILAMIN A IMMUNOGLOBULIN-LIKE REPEAT 10 FROMTITL 2 HOMO SAPIENS.REF ACTA CRYSTALLOGR.,SECT.F V. 67 871 2011REFN ESSN 1744-3091PMID 21821884DOI 10.1107/S1744309111024249 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v5w ADRBK1 human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine 2.07Å AUTH D.M.THAL,K.T.HOMAN,J.CHEN,E.K.WU,P.M.HINKLE,Z.M.HUANG,AUTH 2 J.K.CHUPRUN,J.SONG,E.GAO,J.Y.CHEUNG,L.A.SKLAR,W.J.KOCH,AUTH 3 J.J.TESMERTITL PAROXETINE IS A DIRECT INHIBITOR OF G PROTEIN-COUPLEDTITL 2 RECEPTOR KINASE 2 AND INCREASES MYOCARDIAL CONTRACTILITY.REF ACS CHEM.BIOL. V. 7 1830 2012REFN ISSN 1554-8929PMID 22882301DOI 10.1021/CB3003013 Variant Set Distributions […]
General Structure Information 2e9w KITLG crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) 3.5Å AUTH S.YUZAWA,Y.OPATOWSKY,Z.ZHANG,V.MANDIYAN,I.LAX,J.SCHLESSINGERTITL STRUCTURAL BASIS FOR ACTIVATION OF THE RECEPTOR TYROSINETITL 2 KINASE KIT BY STEM CELL FACTORREF CELL(CAMBRIDGE,MASS.) V. 130 323 2007REFN ISSN 0092-8674PMID 17662946DOI 10.1016/J.CELL.2007.05.055 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2jjd PTPRE protein tyrosine phosphatase, receptor type, e isoform 3.2Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.F.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2m3t CRYGS solution-state nmr structure of wild-type human gamma(s)-crystallin -1.0Å AUTH C.N.KINGSLEY,W.D.BRUBAKER,S.MARKOVIC,A.DIEHL,A.J.BRINDLEY,AUTH 2 H.OSCHKINAT,R.W.MARTINTITL PREFERENTIAL AND SPECIFIC BINDING OF HUMAN ALPHATITL 2 B-CRYSTALLIN TO A CATARACT-RELATED VARIANT OF GAMMATITL 3 S-CRYSTALLIN.REF STRUCTURE V. 21 2221 2013REFN ISSN 0969-2126PMID 24183572DOI 10.1016/J.STR.2013.09.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2bxs MAOA human monoamine oxidase a in complex with clorgyline, crystal form b 3.15Å AUTH L.DE COLIBUS,M.LI,C.BINDA,A.LUSTIG,D.E.EDMONDSON,A.MATTEVITITL THREE-DIMENSIONAL STRUCTURE OF HUMAN MONOAMINE OXIDASE ATITL 2 (MAO A): RELATION TO THE STRUCTURES OF RAT MAO A AND HUMANTITL 3 MAO BREF PROC.NATL.ACAD.SCI.USA V. 102 12864 2005REFN ISSN 0027-8424PMID 16129825DOI 10.1073/PNAS.0505975102 Variant Set Distributions […]
General Structure Information 1pbw PIK3R1 structure of bcr-homology (bh) domain 2.0Å AUTH A.MUSACCHIO,L.C.CANTLEY,S.C.HARRISONTITL CRYSTAL STRUCTURE OF THE BREAKPOINT CLUSTERTITL 2 REGION-HOMOLOGY DOMAIN FROM PHOSPHOINOSITIDETITL 3 3-KINASE P85 ALPHA SUBUNIT.REF PROC.NATL.ACAD.SCI.USA V. 93 14373 1996REFN ISSN 0027-8424PMID 8962058DOI 10.1073/PNAS.93.25.14373 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4iar HTR1B crystal structure of the chimeric protein of 5-ht1b-bril in complex with ergotamine (psi community target) 2.7Å AUTH C.WANG,Y.JIANG,J.MA,H.WU,D.WACKER,V.KATRITCH,G.W.HAN,W.LIU,AUTH 2 X.P.HUANG,E.VARDY,J.D.MCCORVY,X.GAO,X.E.ZHOU,K.MELCHER,AUTH 3 C.ZHANG,F.BAI,H.YANG,L.YANG,H.JIANG,B.L.ROTH,V.CHEREZOV,AUTH 4 R.C.STEVENS,H.E.XUTITL STRUCTURAL BASIS FOR MOLECULAR RECOGNITION AT SEROTONINTITL 2 RECEPTORS.REF SCIENCE V. 340 610 2013REFN ISSN 0036-8075PMID 23519210DOI 10.1126/SCIENCE.1232807 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2h31 PAICS crystal structure of human paics, a bifunctional carboxylase and synthetase in purine biosynthesis 2.8Å AUTH S.X.LI,Y.P.TONG,X.C.XIE,Q.H.WANG,H.N.ZHOU,Y.HAN,Z.Y.ZHANG,AUTH 2 W.GAO,S.G.LI,X.C.ZHANG,R.C.BITITL OCTAMERIC STRUCTURE OF THE HUMAN BIFUNCTIONAL ENZYME PAICSTITL 2 IN PURINE BIOSYNTHESIS.REF J.MOL.BIOL. V. 366 1603 2007REFN ISSN 0022-2836PMID 17224163DOI 10.1016/J.JMB.2006.12.027 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]