General Structure Information
| PDB ID | 2y1m |
| HGNC Gene Label(s) | CBL |
| Structure Name | structure of native c-cbl |
| Resolution | 2.67Å |
| Reference | AUTH H.DOU,L.BUETOW,A.HOCK,G.J.SIBBET,K.H.VOUSDEN,D.T.HUANGTITL STRUCTURAL BASIS FOR AUTOINHIBITION AND PHOSPHORYLATION-TITL 2 DEPENDENT ACTIVATION OF C-CBL.REF NAT.STRUCT.MOL.BIOL. V. 19 184 2012REFN ISSN 1545-9993PMID 22266821DOI 10.1038/NSMB.2231 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 384 |
| Number Of SNVs | 60 |
| Number Of Permutations | 29734 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.016 |
| p-value | 0.177 |
ClinVar
| Number Of Residues | 384 |
| Number Of SNVs | 9 |
| Number Of Permutations | 4312 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.778 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 384 |
| Number Of SNVs | 27 |
| Number Of Permutations | 20777 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.262 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of ClinVar SNVs | 9 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.471 |
| p-value | 0.004 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 60 |
| Number Of COSMIC SNVs | 21 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.418 |
| p-value | 0.0 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
