3V5W.A | ADRBK1

General Structure Information

PDB ID	3v5w
HGNC Gene Label(s)	ADRBK1
Structure Name	human g protein-coupled receptor kinase 2 in complex with soluble gbetagamma subunits and paroxetine
Resolution	2.07Å
Reference	AUTH D.M.THAL,K.T.HOMAN,J.CHEN,E.K.WU,P.M.HINKLE,Z.M.HUANG,AUTH 2 J.K.CHUPRUN,J.SONG,E.GAO,J.Y.CHEUNG,L.A.SKLAR,W.J.KOCH,AUTH 3 J.J.TESMERTITL PAROXETINE IS A DIRECT INHIBITOR OF G PROTEIN-COUPLEDTITL 2 RECEPTOR KINASE 2 AND INCREASES MYOCARDIAL CONTRACTILITY.REF ACS CHEM.BIOL. V. 7 1830 2012REFN ISSN 1554-8929PMID 22882301DOI 10.1021/CB3003013

Variant Set Distributions

ExAC Variants

Number Of Residues	623
Number Of SNVs	128
Number Of Permutations	41314
Optimal Distance Threshold	20.0
K Statistic	0.131
p-value	0.022

COSMIC

Number Of Residues	623
Number Of SNVs	8
Number Of Permutations	3438
Optimal Distance Threshold	7.0
K Statistic	0.036
p-value	0.924

Ripley’s K Analysis Plots

ExACCOSMIC

Variant Set Comparisons

Cosmic vs. ExAC

Number Of ExAC SNVs	128
Number Of COSMIC SNVs	7
Optimal Distance Threshold	7.0
K Statistic	0.037
p-value	0.385

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:67044747		R>C	A:40	(-4.95, 21.70, 34.17)
11:67044778		R>Q	A:50	(-10.06, 7.65, 35.53)
11:67044783		E>K	A:52	(-9.47, 10.39, 40.87)
11:67044801	rs190227928	I>F	A:58	(-6.91, 15.71, 45.92)
11:67046677		L>P	A:66	(1.55, 19.54, 50.49)
11:67046685	COSM4035925 COSM3967778	R>G	A:69	(-0.34, 23.68, 53.29)
11:67046686		R>Q	A:69	(-0.34, 23.68, 53.29)
11:67046697		L>V	A:73	(-1.96, 28.90, 53.89)
11:67046706	rs556538832	L>M	A:76	(-8.15, 31.69, 49.75)
11:67046713		E>A	A:78	(-12.19, 32.29, 52.14)
11:67046714	rs370556389	E>D	A:78	(-12.19, 32.29, 52.14)
11:67046715	rs574869350	A>S	A:79	(-9.17, 29.22, 53.90)
11:67046725		L>S	A:82	(-10.19, 26.52, 58.07)
11:67046907		L>V	A:95	(1.08, 15.40, 71.52)
11:67046910		E>K	A:96	(4.11, 11.11, 72.83)
11:67046914	rs200019576	T>M	A:97	(2.12, 13.05, 76.87)
11:67046919	rs367808517	E>K	A:99	(0.84, 15.45, 80.77)
11:67046941		R>Q	A:106	(-6.86, 25.42, 77.73)
11:67046952		D>N	A:110	(-7.01, 29.90, 74.98)
11:67046961		I>V	A:113	(-6.56, 30.22, 64.96)
11:67046965		M>T	A:114	(-10.64, 29.23, 68.40)
11:67046971	rs139639168	E>G	A:116	(-9.46, 33.97, 63.24)
11:67046986		S>L	A:121	(-18.72, 34.20, 58.73)
11:67046989	rs529567037	H>R	A:122	(-18.25, 30.63, 57.55)
11:67047101		F>S	A:124	(-16.03, 25.93, 64.80)
11:67047104		S>L	A:125	(-20.97, 24.45, 66.25)
11:67047113		A>V	A:128	(-18.73, 21.40, 68.74)
11:67047121		H>N	A:131	(-19.47, 18.02, 72.32)
11:67047122		H>R	A:131	(-19.47, 18.02, 72.32)
11:67047139		G>W	A:137	(-12.86, 21.15, 81.52)
11:67047147		K>N	A:139	(-7.97, 18.35, 82.86)
11:67047148		Q>K	A:140	(-11.90, 14.56, 79.27)
11:67047310		P>S	A:148	(-15.55, 17.74, 66.22)
11:67047311		P>L	A:148	(-15.55, 17.74, 66.22)
11:67047314		Y>C	A:149	(-13.67, 22.04, 66.38)
11:67047316		I>V	A:150	(-11.24, 18.14, 61.64)
11:67047341		R>Q	A:158	(-16.39, 19.12, 51.11)
11:67047346	rs377671393	D>N	A:160	(-16.05, 27.82, 46.69)
11:67047347		D>G	A:160	(-16.05, 27.82, 46.69)
11:67047365	rs370934447	I>T	A:166	(-9.59, 22.79, 40.83)
11:67048247		N>S	A:183	(5.01, 7.72, 33.10)
11:67048249		I>V	A:184	(6.62, 5.35, 37.21)
11:67048250	rs55696045	I>T	A:184	(6.62, 5.35, 37.21)
11:67048565	rs374028985	L>P	A:186	(11.25, 1.61, 37.55)
11:67048571		M>T	A:188	(17.94, -1.95, 37.53)
11:67048598	rs369743896	I>T	A:197	(21.21, -7.01, 52.40)
11:67048624		Y>N	A:206	(21.26, -6.46, 45.85)
11:67048634	COSM1244560	R>Q	A:209	(20.78, 6.22, 47.49)
11:67048934		A>T	A:218	(15.68, -2.62, 49.40)
11:67048939		M>I	A:219	(16.80, -4.14, 44.98)
11:67048958	COSM1704278	R>C	A:226	(17.14, -18.89, 40.45)
11:67048965		K>R	A:228	(10.14, -22.16, 34.77)
11:67048969		M>I	A:229	(14.32, -24.74, 38.20)
11:67049003		I>V	A:241	(-0.91, -9.63, 45.64)
11:67049007		M>T	A:242	(-0.16, -10.08, 49.85)
11:67049018		V>I	A:246	(0.54, -4.66, 53.81)
11:67049122		D>G	A:250	(4.05, 3.96, 57.02)
11:67049148		Y>H	A:259	(8.66, 1.75, 43.90)
11:67049156		F>L	A:261	(11.18, -3.39, 38.91)
11:67049157		H>Y	A:262	(9.49, -6.86, 35.01)
11:67049168	COSM3998548	D>E	A:265	(16.48, -11.89, 34.24)
11:67049343	rs202054233	D>N	A:293	(15.99, -9.59, 75.13)
11:67049346		M>V	A:294	(11.10, -12.13, 73.88)
11:67049347		M>T	A:294	(11.10, -12.13, 73.88)
11:67049349	rs142106623	R>C	A:295	(9.27, -8.51, 77.16)
11:67049350	rs374978008	R>H	A:295	(9.27, -8.51, 77.16)
11:67049355		Y>H	A:297	(13.14, -9.07, 69.36)
11:67049356		Y>F	A:297	(13.14, -9.07, 69.36)
11:67049359		A>V	A:298	(7.14, -9.67, 70.65)
11:67049394		N>D	A:310	(-6.57, -4.87, 60.74)
11:67049395		N>S	A:310	(-6.57, -4.87, 60.74)
11:67049397	rs61891564	R>C	A:311	(-4.54, -3.93, 56.01)
11:67049406		V>I	A:314	(-2.86, -14.72, 57.03)
11:67049775		V>M	A:331	(12.20, -5.77, 64.25)
11:67049812		S>Y	A:343	(-11.68, -11.04, 52.92)
11:67049815		K>R	A:344	(-13.99, -12.14, 49.82)
11:67049820		K>Q	A:346	(-11.76, -18.22, 56.11)
11:67049953	rs138698093	A>V	A:367	(-10.63, -23.45, 57.89)
11:67049958	COSM931026 COSM1731346	D>N	A:369	(-8.33, -16.95, 60.58)
11:67050010		R>Q	A:386	(14.67, -23.56, 75.62)
11:67050236		R>W	A:392	(12.83, -29.55, 65.85)
11:67050254	rs565263383	D>N	A:398	(10.12, -36.71, 60.47)
11:67050269	rs367821561	D>N	A:403	(2.97, -32.42, 62.31)
11:67050272		R>C	A:404	(3.09, -36.64, 66.64)
11:67050275		M>L	A:405	(4.33, -33.51, 68.85)
11:67050279	COSM1475804	T>M	A:406	(1.11, -29.68, 67.29)
11:67050285		T>M	A:408	(-1.23, -34.79, 70.27)
11:67050602		V>M	A:411	(3.76, -27.65, 75.65)
11:67050611		P>S	A:414	(10.20, -24.87, 81.33)
11:67050621		F>S	A:417	(9.80, -20.47, 80.96)
11:67050629		E>K	A:420	(4.86, -13.76, 83.49)
11:67050635		R>C	A:422	(4.25, -20.45, 82.78)
11:67050636	rs1051180	R>H	A:422	(4.25, -20.45, 82.78)
11:67050659		Q>E	A:430	(-4.23, -23.28, 73.65)
11:67050666	rs144705095	D>V	A:432	(-9.01, -24.91, 71.03)
11:67050673		N>K	A:434	(-12.31, -22.19, 70.38)
11:67050674	rs542501875	R>W	A:435	(-9.24, -22.84, 74.70)
11:67050675		R>Q	A:435	(-9.24, -22.84, 74.70)
11:67050687	rs561062604	C>S	A:439	(-8.82, -15.98, 68.96)
11:67050696	rs372392743	R>Q	A:442	(-10.43, -8.24, 72.28)
11:67051194	rs573018580	E>Q	A:449	(-4.71, -7.31, 77.71)
11:67051215	COSM3670873	L>V	A:456	(5.19, -2.79, 77.52)
11:67051228		M>T	A:460	(6.55, 4.37, 73.52)
11:67051235		F>L	A:462	(3.82, 2.45, 66.53)
11:67051334		P>A	A:469	(18.30, -6.26, 72.26)
11:67051350		R>Q	A:474	(28.93, -0.27, 59.74)
11:67051365	rs544703775	A>V	A:479	(23.32, -11.87, 58.06)
11:67051370		D>N	A:481	(22.08, -15.87, 54.32)
11:67051379		D>N	A:484	(19.80, -23.21, 51.44)
11:67051709		R>C	A:507	(0.24, -8.85, 31.39)
11:67051710		R>H	A:507	(0.24, -8.85, 31.39)
11:67051718		P>A	A:510	(4.49, -4.11, 37.24)
11:67051731		S>L	A:514	(0.83, 6.27, 45.63)
11:67051737		R>Q	A:516	(5.35, 3.71, 50.68)
11:67051755		A>V	A:522	(7.92, 14.92, 50.13)
11:67051759	rs370321276	E>D	A:523	(10.77, 12.22, 52.40)
11:67051769		D>N	A:527	(9.70, 21.66, 48.48)
11:67051781	rs139609139	A>T	A:531	(10.98, 26.14, 43.02)
11:67051794	rs373590067	R>Q	A:535	(12.99, 29.34, 39.73)
11:67051803		A>V	A:538	(8.38, 32.72, 35.02)
11:67051805	COSM3869980	R>C	A:539	(12.99, 31.77, 33.49)
11:67051832		G>C	A:548	(4.06, 38.51, 21.75)
11:67052354		Y>C	A:564	(3.86, 19.31, 23.37)
11:67052356		M>V	A:565	(1.49, 14.22, 20.33)
11:67052399	rs140057016	R>Q	A:579	(5.31, 19.49, 15.89)
11:67052425		L>F	A:588	(-6.20, 17.45, 15.07)
11:67052546		Q>E	A:598	(-0.39, 26.75, 9.55)
11:67052562		M>T	A:603	(-12.41, 14.51, 12.78)
11:67052572		I>M	A:606	(-10.46, 10.31, 11.06)
11:67052577		S>L	A:608	(-9.43, 4.50, 12.62)
11:67052589	rs374955195	T>M	A:612	(0.43, 0.61, 17.27)
11:67052604		R>L	A:617	(6.64, 4.21, 22.85)
11:67052627		R>C	A:625	(-11.53, 10.39, 3.69)
11:67052630	rs548308441	G>S	A:626	(-6.75, 7.85, 1.43)
11:67052634		G>A	A:627	(-5.15, 5.30, 2.55)
11:67052760		D>N	A:637	(0.83, 5.82, 29.53)
11:67052772		V>M	A:641	(-5.41, 6.71, 27.54)
11:67052784	rs61763969	K>E	A:645	(-11.64, 8.94, 25.28)
11:67052788		E>V	A:646	(-11.18, 12.66, 23.80)
11:67052794		R>H	A:648	(-11.65, 5.83, 19.58)
11:67052829	COSM1676220	R>W	A:660	(-27.40, 14.77, 11.95)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
11:67048216	COSM1182109	R>W	A:173	(2.97, 22.36, 40.04)
11:67048958	COSM1704278	R>C	A:226	(17.14, -18.89, 40.45)
11:67048967	COSM145073	M>V	A:229	(14.32, -24.74, 38.20)
11:67049760	COSM3452254	D>N	A:326	(17.32, -1.93, 61.91)
11:67051203	COSM1182111	F>L	A:452	(5.55, -11.27, 79.00)
11:67051736	COSM1356368	R>W	A:516	(5.35, 3.71, 50.68)
11:67052453	COSM1736397	P>L	A:597	(-1.70, 26.44, 13.89)
11:67052657	COSM931032	D>N	A:635	(5.34, 12.21, 25.99)

3V5W.A | ADRBK1.

3V5W.A | ADRBK1

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] COSMIC Missense Variants