Assessment of Structural Intolerance and Durability
General Structure Information 3tk9 GZMH crystal structure of human granzyme h 2.2Å AUTH L.WANG,K.ZHANG,L.WU,S.LIU,H.ZHANG,Q.ZHOU,L.TONG,F.SUN,Z.FANTITL STRUCTURAL INSIGHTS INTO THE SUBSTRATE SPECIFICITY OF HUMANTITL 2 GRANZYME H: THE FUNCTIONAL ROLES OF A NOVEL RKR MOTIFREF J.IMMUNOL. V. 188 765 2012REFN ISSN 0022-1767PMID 22156497DOI 10.4049/JIMMUNOL.1101381 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l45 RPS6KB1 crystal structures of human p70s6k1-t389e 2.9Å AUTH J.WANG,C.ZHONG,F.WANG,F.QU,J.DINGTITL CRYSTAL STRUCTURES OF S6K1 PROVIDE INSIGHTS INTO THETITL 2 REGULATION MECHANISM OF S6K1 BY THE HYDROPHOBIC MOTIFREF BIOCHEM.J. V. 454 39 2013REFN ISSN 0264-6021PMID 23731517DOI 10.1042/BJ20121863 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3cmy PAX3 structure of a homeodomain in complex with dna 1.95Å AUTH G.BIRRANE,A.SONI,J.A.LADIASTITL STRUCTURAL BASIS FOR DNA RECOGNITION BY THE HUMAN PAX3TITL 2 HOMEODOMAIN.REF BIOCHEMISTRY V. 48 1148 2009REFN ISSN 0006-2960PMID 19199574DOI 10.1021/BI802052Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3v2w S1PR1 crystal structure of a lipid g protein-coupled receptor at 3.35a 3.35Å AUTH M.A.HANSON,C.B.ROTH,E.JO,M.T.GRIFFITH,F.L.SCOTT,G.REINHART,AUTH 2 H.DESALE,B.CLEMONS,S.M.CAHALAN,S.C.SCHUERER,M.G.SANNA,AUTH 3 G.W.HAN,P.KUHN,H.ROSEN,R.C.STEVENSTITL CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR.REF SCIENCE V. 335 851 2012REFN ISSN 0036-8075PMID 22344443DOI 10.1126/SCIENCE.1215904 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4leo ERBB3 crystal structure of anti-her3 fab rg7116 in complex with the extracellular domains of human her3 (erbb3) 2.64Å AUTH C.MIRSCHBERGER,C.B.SCHILLER,M.SCHRAML,N.DIMOUDIS,T.FRIESS,AUTH 2 C.A.GERDES,U.REIFF,V.LIFKE,G.HOELZLWIMMER,I.KOLM,AUTH 3 K.P.HOPFNER,G.NIEDERFELLNER,B.BOSSENMAIERTITL RG7116, A THERAPEUTIC ANTIBODY THAT BINDS THE INACTIVE HER3TITL 2 RECEPTOR AND IS OPTIMIZED FOR IMMUNE EFFECTOR ACTIVATION.REF CANCER RES. V. 73 5183 2013REFN ISSN 0008-5472PMID 23780344DOI […]
General Structure Information 4fv2 MAPK1 crystal structure of the erk2 complexed with ek5 2.0Å AUTH Y.N.KANG,J.A.STUCKEY,X.XIETITL CRYSTAL STRUCTURE OF THE ERK2 COMPLEXED WITH EK5REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2hev TNFSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4k33 FGFR3 crystal strucure of fgf receptor 3 (fgfr3) kinase domain harboring the k650e mutation, a gain-of-function mutation responsible for thanatophoric dysplasia type ii and spermatocytic seminoma 2.34Å AUTH Z.HUANG,H.CHEN,S.BLAIS,T.A.NEUBERT,X.LI,M.MOHAMMADITITL STRUCTURAL MIMICRY OF A-LOOP TYROSINE PHOSPHORYLATION BY ATITL 2 PATHOGENIC FGF RECEPTOR 3 MUTATION.REF STRUCTURE V. 21 1889 2013REFN ISSN 0969-2126PMID 23972473DOI […]
General Structure Information 2b49 PTPN3 crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 1.54Å AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1h9o PIK3R1 phosphatidylinositol 3-kinase, p85-alpha subunit: c-terminal sh2 domain complexed with a tyr751 phosphopeptide from the pdgf receptor, crystal structure at 1.79 a 1.79Å AUTH R.A.PAUPTIT,C.A.DENNIS,D.J.DERBYSHIRE,A.L.BREEZE,AUTH 2 S.A.WESTON,S.ROWSELL,G.N.MURSHUDOVTITL NMR TRIAL MODELS: EXPERIENCES WITH THE COLICINTITL 2 IMMUNITY PROTEIN IM7 AND THE P85ALPHA C-TERMINALTITL 3 SH2-PEPTIDE COMPLEXREF ACTA CRYSTALLOGR.,SECT.D V. 57 1397 2001REFN […]