General Structure Information
| PDB ID | 2b49 |
| HGNC Gene Label(s) | PTPN3 |
| Structure Name | crystal structure of the catalytic domain of protein tyrosine phosphatase, non-receptor type 3 |
| Resolution | 1.54Å |
| Reference | AUTH A.J.BARR,E.UGOCHUKWU,W.H.LEE,O.N.KING,P.FILIPPAKOPOULOS,AUTH 2 I.ALFANO,P.SAVITSKY,N.A.BURGESS-BROWN,S.MULLER,S.KNAPPTITL LARGE-SCALE STRUCTURAL ANALYSIS OF THE CLASSICAL HUMANTITL 2 PROTEIN TYROSINE PHOSPHATOME.REF CELL(CAMBRIDGE,MASS.) V. 136 352 2009REFN ISSN 0092-8674PMID 19167335DOI 10.1016/J.CELL.2008.11.038 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 259 |
| Number Of SNVs | 77 |
| Number Of Permutations | 8768 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.083 |
| p-value | 0.669 |
COSMIC
| Number Of Residues | 259 |
| Number Of SNVs | 3 |
| Number Of Permutations | 7 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.333 |
| p-value | 0.607 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.229 |
| p-value | 0.769 |