General Structure Information
| PDB ID | 4l45 |
| HGNC Gene Label(s) | RPS6KB1 |
| Structure Name | crystal structures of human p70s6k1-t389e |
| Resolution | 2.9Å |
| Reference | AUTH J.WANG,C.ZHONG,F.WANG,F.QU,J.DINGTITL CRYSTAL STRUCTURES OF S6K1 PROVIDE INSIGHTS INTO THETITL 2 REGULATION MECHANISM OF S6K1 BY THE HYDROPHOBIC MOTIFREF BIOCHEM.J. V. 454 39 2013REFN ISSN 0264-6021PMID 23731517DOI 10.1042/BJ20121863 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 317 |
| Number Of SNVs | 22 |
| Number Of Permutations | 12763 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.022 |
| p-value | 0.743 |
COSMIC
| Number Of Residues | 317 |
| Number Of SNVs | 4 |
| Number Of Permutations | 724 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.167 |
| p-value | 0.396 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 22 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | -0.485 |
| p-value | 0.157 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
