Assessment of Structural Intolerance and Durability
General Structure Information 4l23 PIK3R1 crystal structure of p110alpha complexed with nish2 of p85alpha and pi-103 2.5Å AUTH Y.ZHAO,X.ZHANG,Y.CHEN,S.LU,Y.PENG,X.WANG,C.GUO,A.ZHOU,AUTH 2 J.ZHANG,Y.LUO,Q.SHEN,J.DING,L.MENG,J.ZHANGTITL CRYSTAL STRUCTURES OF PI3K ALPHA COMPLEXED WITH PI103 ANDTITL 2 ITS DERIVATIVES: NEW DIRECTIONS FOR INHIBITORS DESIGN.REF ACS MED CHEM LETT V. 5 138 2014REFN ISSN 1948-5875PMID 24900786DOI 10.1021/ML400378E Variant Set Distributions Ripley’s K […]
General Structure Information 1nfi NFKBIA i-kappa-b-alpha/nf-kappa-b complex 2.7Å AUTH M.D.JACOBS,S.C.HARRISONTITL STRUCTURE OF AN IKAPPABALPHA/NF-KAPPAB COMPLEX.REF CELL(CAMBRIDGE,MASS.) V. 95 749 1998REFN ISSN 0092-8674PMID 9865693DOI 10.1016/S0092-8674(00)81698-0 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4l01 JAK1 crystal structure of the v658f apo jak1 pseudokinase domain 1.9Å AUTH A.V.TOMS,A.DESHPANDE,R.MCNALLY,Y.JEONG,J.M.ROGERS,C.U.KIM,AUTH 2 S.M.GRUNER,S.B.FICARRO,J.A.MARTO,M.SATTLER,J.D.GRIFFIN,AUTH 3 M.J.ECKTITL STRUCTURE OF A PSEUDOKINASE-DOMAIN SWITCH THAT CONTROLSTITL 2 ONCOGENIC ACTIVATION OF JAK KINASES.REF NAT.STRUCT.MOL.BIOL. V. 20 1221 2013REFN ISSN 1545-9993PMID 24013208DOI 10.1038/NSMB.2673 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1nf1 NF1 the gap related domain of neurofibromin 2.5Å AUTH K.SCHEFFZEK,M.R.AHMADIAN,L.WIESMULLER,W.KABSCH,AUTH 2 P.STEGE,F.SCHMITZ,A.WITTINGHOFERTITL STRUCTURAL ANALYSIS OF THE GAP-RELATED DOMAIN FROMTITL 2 NEUROFIBROMIN AND ITS IMPLICATIONS.REF EMBO J. V. 17 4313 1998REFN ISSN 0261-4189PMID 9687500DOI 10.1093/EMBOJ/17.15.4313 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3zfm EPHB2 crystal structure of ephb2 2.27Å AUTH R.C.OVERMAN,J.E.DEBRECZENI,C.M.TRUMAN,M.S.MCALISTER,AUTH 2 T.K.ATTWOODTITL COMPLETING THE STRUCTURAL FAMILY PORTRAIT OF THE HUMAN EPHBTITL 2 TYROSINE KINASE DOMAINSREF PROTEIN SCI. V. 23 627 2014REFN ISSN 0961-8368PMID 24677421DOI 10.1002/PRO.2445 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2pvy FGFR2 crystal strucure of fgf receptor 2 (fgfr2) kinase domain harboring the pathogenic k659n mutation responsible for an unclassified craniosynostosis syndrome. 2.2Å AUTH H.CHEN,J.MA,W.LI,A.V.ELISEENKOVA,C.XU,T.A.NEUBERT,AUTH 2 W.T.MILLER,M.MOHAMMADITITL A MOLECULAR BRAKE IN THE KINASE HINGE REGION REGULATES THETITL 2 ACTIVITY OF RECEPTOR TYROSINE KINASES.REF MOL.CELL V. 27 717 2007REFN ISSN 1097-2765PMID 17803937DOI 10.1016/J.MOLCEL.2007.06.028 […]
General Structure Information 4h1y NT5E human ecto-5-nucleotidase (cd73): crystal form ii (open) in complex with psb11552 1.58Å AUTH K.KNAPP,M.ZEBISCH,J.PIPPEL,A.EL-TAYEB,C.E.MULLER,N.STRATERTITL CRYSTAL STRUCTURE OF THE HUMAN ECTO-5-NUCLEOTIDASE (CD73):TITL 2 INSIGHTS INTO THE REGULATION OF PURINERGIC SIGNALING.REF STRUCTURE V. 20 2161 2012REFN ISSN 0969-2126PMID 23142347DOI 10.1016/J.STR.2012.10.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3jxh PTPRG ca-like domain of human ptprg 1.7Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2irw HSD11B1 human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor 3.1Å AUTH J.R.PATEL,Q.SHUAI,J.DINGES,M.WINN,M.PLIUSHCHEV,S.FUNG,AUTH 2 K.MONZON,W.CHIOU,J.WANG,L.PAN,S.WAGAW,K.ENGSTROM,AUTH 3 F.A.KERDESKY,K.LONGENECKER,R.JUDGE,W.QIN,H.M.IMADE,AUTH 4 D.STOLARIK,D.W.BENO,M.BRUNE,L.E.CHOVAN,H.L.SHAM,P.JACOBSON,AUTH 5 J.T.LINKTITL DISCOVERY OF ADAMANTANE ETHERS AS INHIBITORS OFTITL 2 11BETA-HSD-1: SYNTHESIS AND BIOLOGICAL EVALUATION.REF BIOORG.MED.CHEM.LETT. V. 17 750 2007REFN ISSN 0960-894XPMID 17110106DOI 10.1016/J.BMCL.2006.10.074 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 2qbx EPHB2 ephb2/snew antagonistic peptide complex 2.3Å AUTH J.E.CHRENCIK,A.BROOUN,M.I.RECHT,G.NICOLA,L.K.DAVIS,AUTH 2 R.ABAGYAN,H.WIDMER,E.B.PASQUALE,P.KUHNTITL THREE-DIMENSIONAL STRUCTURE OF THE EPHB2 RECEPTORTITL 2 IN COMPLEX WITH AN ANTAGONISTIC PEPTIDE REVEALS ATITL 3 NOVEL MODE OF INHIBITION.REF J.BIOL.CHEM. V. 282 36505 2007REFN ISSN 0021-9258PMID 17897949DOI 10.1074/JBC.M706340200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants