General Structure Information
| PDB ID | 2irw |
| HGNC Gene Label(s) | HSD11B1 |
| Structure Name | human 11-beta-hydroxysteroid dehydrogenase (hsd1) with nadp and adamantane ether inhibitor |
| Resolution | 3.1Å |
| Reference | AUTH J.R.PATEL,Q.SHUAI,J.DINGES,M.WINN,M.PLIUSHCHEV,S.FUNG,AUTH 2 K.MONZON,W.CHIOU,J.WANG,L.PAN,S.WAGAW,K.ENGSTROM,AUTH 3 F.A.KERDESKY,K.LONGENECKER,R.JUDGE,W.QIN,H.M.IMADE,AUTH 4 D.STOLARIK,D.W.BENO,M.BRUNE,L.E.CHOVAN,H.L.SHAM,P.JACOBSON,AUTH 5 J.T.LINKTITL DISCOVERY OF ADAMANTANE ETHERS AS INHIBITORS OFTITL 2 11BETA-HSD-1: SYNTHESIS AND BIOLOGICAL EVALUATION.REF BIOORG.MED.CHEM.LETT. V. 17 750 2007REFN ISSN 0960-894XPMID 17110106DOI 10.1016/J.BMCL.2006.10.074 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 257 |
| Number Of SNVs | 62 |
| Number Of Permutations | 24466 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.246 |
| p-value | 0.579 |
COSMIC
| Number Of Residues | 257 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4584 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.036 |
| p-value | 0.05 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | -0.146 |
| p-value | 0.133 |