Assessment of Structural Intolerance and Durability
General Structure Information 2×10 EPHA2 crystal structure of the complete epha2 ectodomain 3.0Å AUTH E.SEIRADAKE,K.HARLOS,G.SUTTON,A.R.ARICESCU,AUTH 2 E.Y.JONESTITL AN EXTRACELLULAR STERIC SEEDING MECHANISM FOR EPH-TITL 2 EPHRIN SIGNALLING PLATFORM ASSEMBLYREF NAT.STRUCT.MOL.BIOL. V. 17 398 2010REFN ISSN 1545-9993PMID 20228801DOI 10.1038/NSMB.1782 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2fi2 MZF1 solution structure of the scan homodimer from mzf-1/znf42 -1.0Å AUTH F.C.PETERSON,P.L.HAYES,J.K.WALTNER,A.K.HEISNER,AUTH 2 D.R.JENSEN,T.L.SANDER,B.F.VOLKMANTITL STRUCTURE OF THE SCAN DOMAIN FROM THE TUMORTITL 2 SUPPRESSOR PROTEIN MZF1.REF J.MOL.BIOL. V. 363 137 2006REFN ISSN 0022-2836PMID 16950398DOI 10.1016/J.JMB.2006.07.063 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3bi6 WEE1 wee1 kinase complex with inhibitor pd352396 2.2Å AUTH J.B.SMAILL,H.H.LEE,B.D.PALMER,A.M.THOMPSON,AUTH 2 C.J.SQUIRE,E.N.BAKER,R.J.BOOTH,A.KRAKER,K.HOOK,AUTH 3 W.A.DENNYTITL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SOLUBLE 8-SUBSTITUTEDTITL 3 4-(2-CHLOROPHENYL)-9-HYDROXYPYRROLO[3,4-TITL 4 C]CARBAZOLE-1,3(2H,6H)-DIONES AS INHIBITORS OF THETITL 5 WEE1 AND CHK1 CHECKPOINT KINASES.REF BIOORG.MED.CHEM.LETT. V. 18 929 2008REFN ISSN 0960-894XPMID 18191399DOI 10.1016/J.BMCL.2007.12.046 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3dpe MMP8 crystal structure of the complex between mmp-8 and a non- zinc chelating inhibitor 1.6Å AUTH G.POCHETTI,R.MONTANARI,C.GEGE,C.CHEVRIER,AUTH 2 A.G.TAVERAS,F.MAZZATITL EXTRA BINDING REGION INDUCED BY NON-ZINC CHELATINGTITL 2 INHIBITORS INTO THE S(1) SUBSITE OF MATRIXTITL 3 METALLOPROTEINASE 8 (MMP-8)REF J.MED.CHEM. V. 52 1040 2009REFN ISSN 0022-2623PMID 19173605DOI 10.1021/JM801166J Variant Set Distributions Ripley’s […]
General Structure Information 4hwt TARS crystal structure of human threonyl-trna synthetase bound to a novel inhibitor 2.3Å AUTH M.TENG,M.T.HILGERS,M.L.CUNNINGHAM,A.BORCHARDT,J.B.LOCKE,AUTH 2 S.ABRAHAM,G.HALEY,B.P.KWAN,C.HALL,G.W.HOUGH,K.J.SHAW,J.FINNTITL IDENTIFICATION OF BACTERIA-SELECTIVE THREONYL-TRNATITL 2 SYNTHETASE SUBSTRATE INHIBITORS BY STRUCTURE-BASED DESIGN.REF J.MED.CHEM. V. 56 1748 2013REFN ISSN 0022-2623PMID 23362938DOI 10.1021/JM301756M Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1f4r MPG crystal structure of the human aag dna repair glycosylase complexed with 1,n6-ethenoadenine-dna 2.4Å AUTH A.Y.LAU,M.D.WYATT,B.J.GLASSNER,L.D.SAMSON,AUTH 2 T.ELLENBERGERTITL MOLECULAR BASIS FOR DISCRIMINATING BETWEEN NORMALTITL 2 AND DAMAGED BASES BY THE HUMAN ALKYLADENINETITL 3 GLYCOSYLASE, AAG.REF PROC.NATL.ACAD.SCI.USA V. 97 13573 2000REFN ISSN 0027-8424PMID 11106395DOI 10.1073/PNAS.97.25.13573 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4gj3 TYK2 tyk2 (jh1) in complex with 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2- fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide 2.5Å AUTH J.LIANG,A.VAN ABBEMA,M.BALAZS,K.BARRETT,L.BEREZHKOVSKY,AUTH 2 W.BLAIR,C.CHANG,D.DELAROSA,J.DEVOSS,J.DRISCOLL,C.EIGENBROT,AUTH 3 N.GHILARDI,P.GIBBONS,J.HALLADAY,A.JOHNSON,P.B.KOHLI,Y.LAI,AUTH 4 Y.LIU,J.LYSSIKATOS,P.MANTIK,K.MENGHRAJANI,J.MURRAY,I.PENG,AUTH 5 A.SAMBRONE,S.SHIA,Y.SHIN,J.SMITH,S.SOHN,V.TSUI,M.ULTSCH,AUTH 6 L.C.WU,Y.XIAO,W.YANG,J.YOUNG,B.ZHANG,B.Y.ZHU,S.MAGNUSONTITL LEAD OPTIMIZATION OF A 4-AMINOPYRIDINE BENZAMIDE SCAFFOLD TOTITL 2 IDENTIFY POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE TYK2TITL 3 INHIBITORS.REF J.MED.CHEM. V. 56 4521 2013REFN ISSN 0022-2623PMID 23668484DOI 10.1021/JM400266T Variant Set […]
General Structure Information 4asx ACVR2A crystal structure of activin receptor type-iia (acvr2a) kinase domain in complex with dihydro-bauerine c 2.05Å AUTH E.WILLIAMS,A.CHAIKUAD,P.CANNING,P.MAHAJAN,C.D.O.COOPER,AUTH 2 A.BELTRAMI,T.KROJER,K.HUBER,F.BRACHER,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,A.BULLOCKTITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE-IIA ( ACVR2A)TITL 2 KINASE DOMAIN IN COMPLEX WITH A BETA- CARBOLINE INHIBITORREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bic MUT crystal structure of human methylmalonyl-coa mutase 2.6Å AUTH D.S.FROESE,G.KOCHAN,J.R.MUNIZ,X.WU,C.GILEADI,E.UGOCHUKWU,AUTH 2 E.KRYSZTOFINSKA,R.A.GRAVEL,U.OPPERMANN,W.W.YUETITL STRUCTURES OF THE HUMAN GTPASE MMAA AND VITAMINTITL 2 B12-DEPENDENT METHYLMALONYL-COA MUTASE AND INSIGHT INTOTITL 3 THEIR COMPLEX FORMATION.REF J.BIOL.CHEM. V. 285 38204 2010REFN ISSN 0021-9258PMID 20876572DOI 10.1074/JBC.M110.177717 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 1e5w MSN structure of isolated ferm domain and first long helix of moesin 2.7Å AUTH S.D.EDWARDS,N.H.KEEPTITL THE 2.7 A CRYSTAL STRUCTURE OF THE ACTIVATED FERMTITL 2 DOMAIN OF MOESIN: AN ANALYSIS OF STRUCTURALTITL 3 CHANGES ON ACTIVATIONREF BIOCHEMISTRY V. 40 7061 2001REFN ISSN 0006-2960PMID 11401550DOI 10.1021/BI010419H Variant Set Distributions Ripley’s K Analysis […]