General Structure Information
| PDB ID | 4hwt |
| HGNC Gene Label(s) | TARS |
| Structure Name | crystal structure of human threonyl-trna synthetase bound to a novel inhibitor |
| Resolution | 2.3Å |
| Reference | AUTH M.TENG,M.T.HILGERS,M.L.CUNNINGHAM,A.BORCHARDT,J.B.LOCKE,AUTH 2 S.ABRAHAM,G.HALEY,B.P.KWAN,C.HALL,G.W.HOUGH,K.J.SHAW,J.FINNTITL IDENTIFICATION OF BACTERIA-SELECTIVE THREONYL-TRNATITL 2 SYNTHETASE SUBSTRATE INHIBITORS BY STRUCTURE-BASED DESIGN.REF J.MED.CHEM. V. 56 1748 2013REFN ISSN 0022-2623PMID 23362938DOI 10.1021/JM301756M |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 402 |
| Number Of SNVs | 101 |
| Number Of Permutations | 26407 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.026 |
| p-value | 0.235 |
COSMIC
| Number Of Residues | 402 |
| Number Of SNVs | 3 |
| Number Of Permutations | 253 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 101 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 41.0 |
| K Statistic | -0.375 |
| p-value | 0.757 |