General Structure Information
| PDB ID | 1f4r |
| HGNC Gene Label(s) | MPG |
| Structure Name | crystal structure of the human aag dna repair glycosylase complexed with 1,n6-ethenoadenine-dna |
| Resolution | 2.4Å |
| Reference | AUTH A.Y.LAU,M.D.WYATT,B.J.GLASSNER,L.D.SAMSON,AUTH 2 T.ELLENBERGERTITL MOLECULAR BASIS FOR DISCRIMINATING BETWEEN NORMALTITL 2 AND DAMAGED BASES BY THE HUMAN ALKYLADENINETITL 3 GLYCOSYLASE, AAG.REF PROC.NATL.ACAD.SCI.USA V. 97 13573 2000REFN ISSN 0027-8424PMID 11106395DOI 10.1073/PNAS.97.25.13573 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 199 |
| Number Of SNVs | 74 |
| Number Of Permutations | 21113 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.035 |
| p-value | 0.985 |
COSMIC
| Number Of Residues | 199 |
| Number Of SNVs | 4 |
| Number Of Permutations | 509 |
| Optimal Distance Threshold | 36.0 |
| K Statistic | 0.833 |
| p-value | 0.38 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 74 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | -0.419 |
| p-value | 0.048 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
