Assessment of Structural Intolerance and Durability
General Structure Information 2r83 SYT1 crystal structure analysis of human synaptotagmin 1 c2a-c2b 2.7Å AUTH K.L.FUSON,M.MONTES,J.J.ROBERT,R.B.SUTTONTITL STRUCTURE OF HUMAN SYNAPTOTAGMIN 1 C2AB IN THETITL 2 ABSENCE OF CA2+ REVEALS A NOVEL DOMAIN ASSOCIATION.REF BIOCHEMISTRY V. 46 13041 2007REFN ISSN 0006-2960PMID 17956130DOI 10.1021/BI701651K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 4c6f CAD crystal structure of the dihydroorotase domain of human cad bound to substrate at ph 6.5 1.26Å AUTH A.GRANDE-GARCIA,N.LALLOUS,C.DIAZ-TEJADA,S.RAMON-MAIQUESTITL STRUCTURE, FUNCTIONAL CHARACTERIZATION AND EVOLUTION OF THETITL 2 DIHYDROOROTASE DOMAIN OF HUMAN CAD.REF STRUCTURE V. 22 185 2014REFN ISSN 0969-2126PMID 24332717DOI 10.1016/J.STR.2013.10.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1t7y AZGP1 zn-alpha-2-glycoprotein; baculo-zag peg 200, no glycerol 2.8Å AUTH S.L.DELKER,A.P.WEST JR.,L.MCDERMOTT,M.W.KENNEDY,P.J.BJORKMANTITL CRYSTALLOGRAPHIC STUDIES OF LIGAND BINDING BYTITL 2 ZN-ALPHA2-GLYCOPROTEIN.REF J.STRUCT.BIOL. V. 148 205 2004REFN ISSN 1047-8477PMID 15477100DOI 10.1016/J.JSB.2004.04.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ksa TACR1 substance p in dmpc/chaps isotropic q=0.25 bicelles as a ligand for nk1r -1.0Å AUTH A.GAYEN,S.K.GOSWAMI,C.MUKHOPADHYAYTITL NMR EVIDENCE OF GM1-INDUCED CONFORMATIONAL CHANGE OFTITL 2 SUBSTANCE P USING ISOTROPIC BICELLESREF BIOCHIM.BIOPHYS.ACTA 2010REFN ISSN 0006-3002PMID 20937248DOI 10.1016/J.BBAMEM.2010.09.023 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3jxf PTPRZ1 ca-like domain of human ptprz 2.0Å AUTH S.BOUYAIN,D.J.WATKINSTITL THE PROTEIN TYROSINE PHOSPHATASES PTPRZ AND PTPRGTITL 2 BIND TO DISTINCT MEMBERS OF THE CONTACTIN FAMILY OFTITL 3 NEURAL RECOGNITION MOLECULES.REF PROC.NATL.ACAD.SCI.USA V. 107 2443 2010REFN ISSN 0027-8424PMID 20133774DOI 10.1073/PNAS.0911235107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4kxu TKT human transketolase in covalent complex with donor ketose d-fructose- 6-phosphate 0.98Å AUTH S.LUDTKE,P.NEUMANN,K.M.ERIXON,F.LEEPER,R.KLUGER,R.FICNER,AUTH 2 K.TITTMANNTITL SUB-ANGSTROM-RESOLUTION CRYSTALLOGRAPHY REVEALS PHYSICALTITL 2 DISTORTIONS THAT ENHANCE REACTIVITY OF A COVALENT ENZYMATICTITL 3 INTERMEDIATE.REF NAT CHEM V. 5 762 2013REFNPMID 23965678DOI 10.1038/NCHEM.1728 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3dzf CD38 crystal structure of human cd38 extracellular domain complexed with a covalent intermediate, ara-f-ribose-5-phosphate 2.01Å AUTH Q.LIU,I.A.KRIKSUNOV,H.JIANG,R.GRAEFF,H.LIN,H.C.LEE,Q.HAOTITL COVALENT AND NONCOVALENT INTERMEDIATES OF AN NAD UTILIZINGTITL 2 ENZYME, HUMAN CD38.REF CHEM.BIOL. V. 15 1068 2008REFN ISSN 1074-5521PMID 18940667DOI 10.1016/J.CHEMBIOL.2008.08.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3i8v PDE4A crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone 2.25Å AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1a7a AHCY structure of human placental s-adenosylhomocysteine hydrolase: determination of a 30 selenium atom substructure from data at a single wavelength 2.8Å AUTH M.A.TURNER,C.S.YUAN,R.T.BORCHARDT,M.S.HERSHFIELD,G.D.SMITH,AUTH 2 P.L.HOWELLTITL STRUCTURE DETERMINATION OF SELENOMETHIONYLTITL 2 S-ADENOSYLHOMOCYSTEINE HYDROLASE USING DATA AT A SINGLETITL 3 WAVELENGTH.REF NAT.STRUCT.BIOL. V. 5 369 1998REFN ISSN 1072-8368PMID 9586999DOI 10.1038/NSB0598-369 Variant Set Distributions […]
General Structure Information 2fy5 CHAT structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis 2.6Å AUTH A.R.KIM,R.J.RYLETT,B.H.SHILTONTITL SUBSTRATE BINDING AND CATALYTIC MECHANISM OF HUMANTITL 2 CHOLINE ACETYLTRANSFERASE.REF BIOCHEMISTRY V. 45 14621 2006REFN ISSN 0006-2960PMID 17144655DOI 10.1021/BI061536L Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants