General Structure Information
| PDB ID | 3i8v |
| HGNC Gene Label(s) | PDE4A |
| Structure Name | crystal structure of human pde4a with 4-(3-butoxy-4-methoxyphenyl) methyl-2-imidazolidone |
| Resolution | 2.25Å |
| Reference | AUTH R.K.Y.CHENG,L.CRAWLEY,J.BARKER,M.WOOD,B.FELICETTI,AUTH 2 M.WHITTAKERTITL CRYSTAL STRUCTURE OF HUMAN PDE4A WITHTITL 2 4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONEREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 332 |
| Number Of SNVs | 59 |
| Number Of Permutations | 27012 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.036 |
| p-value | 0.854 |
COSMIC
| Number Of Residues | 332 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1987 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.3 |
| p-value | 0.905 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.18 |
| p-value | 0.857 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
