General Structure Information
| PDB ID | 3bi6 |
| HGNC Gene Label(s) | WEE1 |
| Structure Name | wee1 kinase complex with inhibitor pd352396 |
| Resolution | 2.2Å |
| Reference | AUTH J.B.SMAILL,H.H.LEE,B.D.PALMER,A.M.THOMPSON,AUTH 2 C.J.SQUIRE,E.N.BAKER,R.J.BOOTH,A.KRAKER,K.HOOK,AUTH 3 W.A.DENNYTITL SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OFTITL 2 SOLUBLE 8-SUBSTITUTEDTITL 3 4-(2-CHLOROPHENYL)-9-HYDROXYPYRROLO[3,4-TITL 4 C]CARBAZOLE-1,3(2H,6H)-DIONES AS INHIBITORS OF THETITL 5 WEE1 AND CHK1 CHECKPOINT KINASES.REF BIOORG.MED.CHEM.LETT. V. 18 929 2008REFN ISSN 0960-894XPMID 18191399DOI 10.1016/J.BMCL.2007.12.046 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 258 |
| Number Of SNVs | 40 |
| Number Of Permutations | 5347 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.068 |
| p-value | 0.231 |
COSMIC
| Number Of Residues | 258 |
| Number Of SNVs | 3 |
| Number Of Permutations | 46 |
| Optimal Distance Threshold | 17.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
