General Structure Information
| PDB ID | 4l23 |
| HGNC Gene Label(s) | PIK3R1 |
| Structure Name | crystal structure of p110alpha complexed with nish2 of p85alpha and pi-103 |
| Resolution | 2.5Å |
| Reference | AUTH Y.ZHAO,X.ZHANG,Y.CHEN,S.LU,Y.PENG,X.WANG,C.GUO,A.ZHOU,AUTH 2 J.ZHANG,Y.LUO,Q.SHEN,J.DING,L.MENG,J.ZHANGTITL CRYSTAL STRUCTURES OF PI3K ALPHA COMPLEXED WITH PI103 ANDTITL 2 ITS DERIVATIVES: NEW DIRECTIONS FOR INHIBITORS DESIGN.REF ACS MED CHEM LETT V. 5 138 2014REFN ISSN 1948-5875PMID 24900786DOI 10.1021/ML400378E |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 277 |
| Number Of SNVs | 29 |
| Number Of Permutations | 14389 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.177 |
| p-value | 0.672 |
ClinVar
| Number Of Residues | 277 |
| Number Of SNVs | 3 |
| Number Of Permutations | 484 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.634 |
COSMIC
| Number Of Residues | 277 |
| Number Of SNVs | 15 |
| Number Of Permutations | 27809 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.152 |
| p-value | 0.235 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.294 |
| p-value | 0.461 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 29 |
| Number Of COSMIC SNVs | 13 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.053 |
| p-value | 0.201 |