General Structure Information
| PDB ID | 4l01 |
| HGNC Gene Label(s) | JAK1 |
| Structure Name | crystal structure of the v658f apo jak1 pseudokinase domain |
| Resolution | 1.9Å |
| Reference | AUTH A.V.TOMS,A.DESHPANDE,R.MCNALLY,Y.JEONG,J.M.ROGERS,C.U.KIM,AUTH 2 S.M.GRUNER,S.B.FICARRO,J.A.MARTO,M.SATTLER,J.D.GRIFFIN,AUTH 3 M.J.ECKTITL STRUCTURE OF A PSEUDOKINASE-DOMAIN SWITCH THAT CONTROLSTITL 2 ONCOGENIC ACTIVATION OF JAK KINASES.REF NAT.STRUCT.MOL.BIOL. V. 20 1221 2013REFN ISSN 1545-9993PMID 24013208DOI 10.1038/NSMB.2673 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 38 |
| Number Of Permutations | 5299 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.267 |
| p-value | 0.077 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 11 |
| Number Of Permutations | 4916 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.055 |
| p-value | 0.361 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 38 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.092 |
| p-value | 0.835 |