General Structure Information
| PDB ID | 2e9w |
| HGNC Gene Label(s) | KITLG |
| Structure Name | crystal structure of the extracellular domain of kit in complex with stem cell factor (scf) |
| Resolution | 3.5Å |
| Reference | AUTH S.YUZAWA,Y.OPATOWSKY,Z.ZHANG,V.MANDIYAN,I.LAX,J.SCHLESSINGERTITL STRUCTURAL BASIS FOR ACTIVATION OF THE RECEPTOR TYROSINETITL 2 KINASE KIT BY STEM CELL FACTORREF CELL(CAMBRIDGE,MASS.) V. 130 323 2007REFN ISSN 0092-8674PMID 17662946DOI 10.1016/J.CELL.2007.05.055 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 128 |
| Number Of SNVs | 21 |
| Number Of Permutations | 7622 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.033 |
| p-value | 0.79 |
ClinVar
| Number Of Residues | 128 |
| Number Of SNVs | 3 |
| Number Of Permutations | 155 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.667 |
| p-value | 0.004 |
COSMIC
| Number Of Residues | 128 |
| Number Of SNVs | 6 |
| Number Of Permutations | 391 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.133 |
| p-value | 0.832 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.657 |
| p-value | 0.002 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 21 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.343 |
| p-value | 0.578 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
