General Structure Information
| PDB ID | 2h31 |
| HGNC Gene Label(s) | PAICS |
| Structure Name | crystal structure of human paics, a bifunctional carboxylase and synthetase in purine biosynthesis |
| Resolution | 2.8Å |
| Reference | AUTH S.X.LI,Y.P.TONG,X.C.XIE,Q.H.WANG,H.N.ZHOU,Y.HAN,Z.Y.ZHANG,AUTH 2 W.GAO,S.G.LI,X.C.ZHANG,R.C.BITITL OCTAMERIC STRUCTURE OF THE HUMAN BIFUNCTIONAL ENZYME PAICSTITL 2 IN PURINE BIOSYNTHESIS.REF J.MOL.BIOL. V. 366 1603 2007REFN ISSN 0022-2836PMID 17224163DOI 10.1016/J.JMB.2006.12.027 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 380 |
| Number Of SNVs | 76 |
| Number Of Permutations | 48072 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.224 |
| p-value | 0.055 |
COSMIC
| Number Of Residues | 380 |
| Number Of SNVs | 3 |
| Number Of Permutations | 498 |
| Optimal Distance Threshold | 59.0 |
| K Statistic | 0.333 |
| p-value | 0.036 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 76 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 32.0 |
| K Statistic | -0.476 |
| p-value | 0.211 |