Assessment of Structural Intolerance and Durability
General Structure Information 2c0m PEX5 apo form of the tpr domain of the pex5p receptor 2.5Å AUTH W.A.STANLEY,F.V.FILIPP,P.KURSULA,N.SCHULLER,AUTH 2 R.ERDMANN,W.SCHLIEBS,M.SATTLER,M.WILMANNSTITL RECOGNITION OF A FUNCTIONAL PEROXISOME TYPE 1TITL 2 TARGET BY THE DYNAMIC IMPORT RECEPTOR PEX5P.REF MOL.CELL V. 24 653 2006REFN ISSN 1097-2765PMID 17157249DOI 10.1016/J.MOLCEL.2006.10.024 Variant Set Distributions Mapped Variants
General Structure Information 1du3 TNFSF10 crystal structure of trail-sdr5 2.2Å AUTH S.-S.CHA,B.-J.SUNG,Y.A.KIM,Y.L.SONG,H.J.KIM,S.KIM,AUTH 2 M.S.LEE,B.-H.OHTITL CRYSTAL STRUCTURE OF TRAIL-DR5 COMPLEX IDENTIFIESTITL 2 A CRITICAL ROLE OF THE UNIQUE FRAME INSERTION INTITL 3 CONFERRING RECOGNITION SPECIFICITYREF J.BIOL.CHEM. V. 275 31171 2000REFN ISSN 0021-9258PMID 10893238DOI 10.1074/JBC.M004414200 Variant Set Distributions Mapped Variants
General Structure Information 4efg RBP2 crystal structure of the q108k:k40l:t51v:t53c:y19w:r58w:t29l mutant of cellular retinol binding protein type ii in complex with all-trans- retinal at 1.58 angstrom resolution 1.58Å AUTH W.WANG,Z.NOSSONI,T.BERBASOVA,C.T.WATSON,I.YAPICI,K.S.LEE,AUTH 2 C.VASILEIOU,J.H.GEIGER,B.BORHANTITL TUNING THE ELECTRONIC ABSORPTION OF PROTEIN-EMBEDDEDTITL 2 ALL-TRANS-RETINAL.REF SCIENCE V. 338 1340 2012REFN ISSN 0036-8075PMID 23224553DOI 10.1126/SCIENCE.1226135 Variant Set Distributions Mapped Variants
General Structure Information 3s95 LIMK1 crystal structure of the human limk1 kinase domain in complex with staurosporine 1.65Å AUTH A.BELTRAMI,A.CHAIKUAD,N.DAGA,J.M.ELKINS,P.MAHAJAN,AUTH 2 P.SAVITSKY,M.VOLLMAR,T.KROJER,J.R.C.MUNIZ,O.FEDOROV,AUTH 3 C.K.ALLERSTON,W.W.YUE,O.GILEADI,F.VON DELFT,C.H.ARROWSMITH,AUTH 4 A.M.EDWARDS,J.WEIGELT,C.BOUNTRA,S.KNAPP,A.BULLOCKTITL CRYSTAL STRUCTURE OF THE HUMAN LIMK1 KINASE DOMAIN INTITL 2 COMPLEX WITH STAUROSPORINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 2ea2 METAP2 h-metap2 complexed with a773812 2.5Å AUTH G.T.WANG,R.A.MANTEI,M.KAWAI,J.S.TEDROW,D.M.BARNES,AUTH 2 J.WANG,Q.ZHANG,P.LOU,L.A.GARCIA,J.BOUSKA,M.YATES,AUTH 3 C.PARK,R.A.JUDGE,R.LESNIEWSKI,G.S.SHEPPARD,R.L.BELLTITL LEAD OPTIMIZATION OF METHIONINE AMINOPEPTIDASE-2TITL 2 (METAP2) INHIBITORS CONTAINING SULFONAMIDES OFTITL 3 5,6-DISUBSTITUTED ANTHRANILIC ACIDSREF BIOORG.MED.CHEM.LETT. V. 17 2817 2007REFN ISSN 0960-894XPMID 17350258DOI 10.1016/J.BMCL.2007.02.062 Variant Set Distributions Mapped Variants
General Structure Information 3tl5 PIK3CG discovery of gdc-0980: a potent, selective, and orally available class i phosphatidylinositol 3-kinase (pi3k)/mammalian target of rapamycin (mtor) kinase inhibitor for the treatment of cancer 2.79Å AUTH D.P.SUTHERLIN,L.BAO,M.BERRY,G.CASTANEDO,I.CHUCKOWREE,AUTH 2 J.DOTSON,A.FOLKS,L.FRIEDMAN,R.GOLDSMITH,J.GUNZNER,T.HEFFRON,AUTH 3 J.LESNICK,C.LEWIS,S.MATHIEU,J.MURRAY,J.NONOMIYA,J.PANG,AUTH 4 N.PEGG,W.W.PRIOR,L.ROUGE,L.SALPHATI,D.SAMPATH,Q.TIAN,V.TSUI,AUTH 5 N.C.WAN,S.WANG,B.WEI,C.WIESMANN,P.WU,B.Y.ZHU,A.OLIVEROTITL DISCOVERY OF A POTENT, SELECTIVE, AND ORALLY AVAILABLE CLASSTITL 2 I PHOSPHATIDYLINOSITOL 3-KINASE (PI3K)/MAMMALIAN […]
General Structure Information 1zr0 TFPI2 crystal structure of kunitz domain 1 of tissue factor pathway inhibitor-2 with bovine trypsin 1.8Å AUTH A.E.SCHMIDT,H.S.CHAND,D.CASCIO,W.KISIEL,S.P.BAJAJTITL CRYSTAL STRUCTURE OF KUNITZ DOMAIN 1 (KD1) OFTITL 2 TISSUE FACTOR PATHWAY INHIBITOR-2 IN COMPLEX WITHTITL 3 TRYPSIN. IMPLICATIONS FOR KD1 SPECIFICITY OFTITL 4 INHIBITIONREF J.BIOL.CHEM. V. 280 27832 2005REFN ISSN 0021-9258PMID 15932872DOI […]
General Structure Information 4nw5 RPS6KA3 rsk2 n-terminal kinase in complex with 2-amino-7-substituted benzoxazole compound 8 1.94Å AUTH A.COSTALES,M.MATHUR,S.RAMURTHY,J.LAN,S.SUBRAMANIAN,R.JAIN,AUTH 2 G.ATALLAH,L.SETTI,M.LINDVALL,B.A.APPLETON,E.ORNELAS,AUTH 3 P.FEUCHT,B.WARNE,L.DOYLE,S.E.BASHAM,I.ARONCHIK,AUTH 4 A.B.JEFFERSON,C.M.SHAFERTITL 2-AMINO-7-SUBSTITUTED BENZOXAZOLE ANALOGS AS POTENT RSK2TITL 2 INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 24 1592 2014REFN ISSN 0960-894XPMID 24534486DOI 10.1016/J.BMCL.2014.01.058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 4f7s CDK8 crystal structure of human cdk8/cycc in the dmg-in conformation 2.2Å AUTH E.V.SCHNEIDER,J.BOTTCHER,R.HUBER,K.MASKOS,L.NEUMANNTITL STRUCTURE-KINETIC RELATIONSHIP STUDY OF CDK8/CYCC SPECIFICTITL 2 COMPOUNDS.REF PROC.NATL.ACAD.SCI.USA V. 110 8081 2013REFN ISSN 0027-8424PMID 23630251DOI 10.1073/PNAS.1305378110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1bqq MMP14 crystal structure of the mt1-mmp–timp-2 complex 2.75Å AUTH C.FERNANDEZ-CATALAN,W.BODE,R.HUBER,D.TURK,AUTH 2 J.J.CALVETE,A.LICHTE,H.TSCHESCHE,K.MASKOSTITL CRYSTAL STRUCTURE OF THE COMPLEX FORMED BY THETITL 2 MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE WITH THETITL 3 TISSUE INHIBITOR OF METALLOPROTEINASES-2, THETITL 4 SOLUBLE PROGELATINASE A RECEPTOR.REF EMBO J. V. 17 5238 1998REFN ISSN 0261-4189PMID 9724659DOI 10.1093/EMBOJ/17.17.5238 Variant Set Distributions […]