Assessment of Structural Intolerance and Durability
General Structure Information 3kbt SPTB crystal structure of the ankyrin binding domain of human erythroid beta spectrin (repeats 13-15) in complex with the spectrin binding domain of human erythroid ankyrin (zu5-ank) 2.75Å AUTH J.J.IPSARO,A.MONDRAGONTITL STRUCTURAL BASIS FOR SPECTRIN RECOGNITION BY ANKYRIN.REF BLOOD V. 115 4093 2010REFN ISSN 0006-4971PMID 20101027DOI 10.1182/BLOOD-2009-11-255604 Variant Set Distributions Ripley’s K […]
General Structure Information 3lbx SPTB crystal structure of the erythrocyte spectrin tetramerization domain complex 2.8Å AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2c7a PGR structure of the progesterone receptor-dna complex 2.5Å AUTH S.C.ROEMER,D.C.DONHAM,L.SHERMAN,V.H.PON,AUTH 2 D.P.EDWARDS,M.E.A.CHURCHILLTITL STRUCTURE OF THE PROGESTERONE RECEPTOR-TITL 2 DEOXYRIBONUCLEIC ACID COMPLEX: NOVEL INTERACTIONSTITL 3 REQUIRED FOR BINDING TO HALF-SITE RESPONSETITL 4 ELEMENTS.REF MOL.ENDOCRINOL. V. 20 3042 2006REFN ISSN 0888-8809PMID 16931575DOI 10.1210/ME.2005-0511 Variant Set Distributions Mapped Variants
General Structure Information 1uea TIMP1 mmp-3/timp-1 complex 2.8Å AUTH F.X.GOMIS-RUTH,K.MASKOS,M.BETZ,A.BERGNER,R.HUBER,AUTH 2 K.SUZUKI,N.YOSHIDA,H.NAGASE,K.BREW,G.P.BOURENKOV,AUTH 3 H.BARTUNIK,W.BODETITL MECHANISM OF INHIBITION OF THE HUMAN MATRIXTITL 2 METALLOPROTEINASE STROMELYSIN-1 BY TIMP-1.REF NATURE V. 389 77 1997REFN ISSN 0028-0836PMID 9288970DOI 10.1038/37995 Variant Set Distributions Mapped Variants
General Structure Information 2wo3 EFNA2 crystal structure of the epha4-ephrina2 complex 2.35Å AUTH T.A.BOWDEN,A.R.ARICESCU,J.E.NETTLESHIP,C.SIEBOLD,AUTH 2 N.RAHMAN-HUQ,R.J.OWENS,D.I.STUART,E.Y.JONESTITL STRUCTURAL PLASTICITY OF EPH-RECEPTOR A4 FACILITATESTITL 2 CROSS-CLASS EPHRIN SIGNALLINGREF STRUCTURE V. 17 1386 2009REFN ISSN 0969-2126PMID 19836338DOI 10.1016/J.STR.2009.07.018 Variant Set Distributions Mapped Variants
General Structure Information 3l6y CTNND1 crystal structure of p120 catenin in complex with e-cadherin 3.0Å AUTH N.ISHIYAMA,S.H.LEE,S.LIU,G.Y.LI,M.J.SMITH,L.F.REICHARDT,AUTH 2 M.IKURATITL DYNAMIC AND STATIC INTERACTIONS BETWEEN P120 CATENIN ANDTITL 2 E-CADHERIN REGULATE THE STABILITY OF CELL-CELL ADHESION.REF CELL(CAMBRIDGE,MASS.) V. 141 117 2010REFN ISSN 0092-8674PMID 20371349DOI 10.1016/J.CELL.2010.01.017 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2kup FRS3 solution structure of the complex of the ptb domain of snt-2 and 19- residue peptide (aa 1571-1589) of halk -1.0Å AUTH S.KOSHIBA,H.LI,Y.MOTODA,T.TOMIZAWA,T.KASAI,N.TOCHIO,AUTH 2 T.YABUKI,T.HARADA,S.WATANABE,A.TANAKA,M.SHIROUZU,T.KIGAWA,AUTH 3 T.YAMAMOTO,S.YOKOYAMATITL STRUCTURAL BASIS FOR THE RECOGNITION OFTITL 2 NUCLEOPHOSMIN-ANAPLASTIC LYMPHOMA KINASE ONCOPROTEIN BY THETITL 3 PHOSPHOTYROSINE BINDING DOMAIN OF SUC1-ASSOCIATEDTITL 4 NEUROTROPHIC FACTOR-INDUCED TYROSINE-PHOSPHORYLATED TARGET-2REF […]
General Structure Information 1du3 TNFRSF10B crystal structure of trail-sdr5 2.2Å AUTH S.-S.CHA,B.-J.SUNG,Y.A.KIM,Y.L.SONG,H.J.KIM,S.KIM,AUTH 2 M.S.LEE,B.-H.OHTITL CRYSTAL STRUCTURE OF TRAIL-DR5 COMPLEX IDENTIFIESTITL 2 A CRITICAL ROLE OF THE UNIQUE FRAME INSERTION INTITL 3 CONFERRING RECOGNITION SPECIFICITYREF J.BIOL.CHEM. V. 275 31171 2000REFN ISSN 0021-9258PMID 10893238DOI 10.1074/JBC.M004414200 Variant Set Distributions Mapped Variants