General Structure Information
| PDB ID | 3lbx |
| HGNC Gene Label(s) | SPTB |
| Structure Name | crystal structure of the erythrocyte spectrin tetramerization domain complex |
| Resolution | 2.8Å |
| Reference | AUTH J.J.IPSARO,S.L.HARPER,T.E.MESSICK,R.MARMORSTEIN,A.MONDRAGON,AUTH 2 D.W.SPEICHERTITL CRYSTAL STRUCTURE AND FUNCTIONAL INTERPRETATION OF THETITL 2 ERYTHROCYTE SPECTRIN TETRAMERIZATION DOMAIN COMPLEX.REF BLOOD V. 115 4843 2010REFN ISSN 0006-4971PMID 20197550DOI 10.1182/BLOOD-2010-01-261396 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 180 |
| Number Of SNVs | 50 |
| Number Of Permutations | 51088 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.264 |
| p-value | 0.468 |
ClinVar
| Number Of Residues | 180 |
| Number Of SNVs | 5 |
| Number Of Permutations | 3701 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.6 |
| p-value | 0.01 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 50 |
| Number Of ClinVar SNVs | 5 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.464 |
| p-value | 0.012 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
