Assessment of Structural Intolerance and Durability
General Structure Information 2qrv DNMT3A structure of dnmt3a-dnmt3l c-terminal domain complex 2.89Å AUTH D.JIA,R.Z.JURKOWSKA,X.ZHANG,A.JELTSCH,X.CHENGTITL STRUCTURE OF DNMT3A BOUND TO DNMT3L SUGGESTS ATITL 2 MODEL FOR DE NOVO DNA METHYLATION.REF NATURE V. 449 248 2007REFN ISSN 0028-0836PMID 17713477DOI 10.1038/NATURE06146 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qfv CDC42BPB mrck beta in complex with tpca-1 2.65Å AUTH T.HEIKKILA,E.WHEATLEY,D.CRIGHTON,E.SCHRODER,A.BOAKES,AUTH 2 S.J.KAYE,M.MEZNA,L.PANG,M.RUSHBROOKE,A.TURNBULL,M.F.OLSONTITL CO-CRYSTAL STRUCTURES OF INHIBITORS WITH MRCK BETA , A KEYTITL 2 REGULATOR OF TUMOR CELL INVASION.REF PLOS ONE V. 6 24825 2011REFN ESSN 1932-6203PMID 21949762DOI 10.1371/JOURNAL.PONE.0024825 Variant Set Distributions Mapped Variants
General Structure Information 2vpd PYGO1 decoding of methylated histone h3 tail by the pygo-bcl9 wnt signaling complex 2.77Å AUTH M.FIEDLER,M.J.SANCHEZ-BARRENA,M.NEKRASOV,AUTH 2 J.MIESZCZANEK,V.RYBIN,J.MULLER,P.EVANS,M.BIENZTITL DECODING OF METHYLATED HISTONE H3 TAIL BY THETITL 2 PYGO- BCL9 WNT SIGNALING COMPLEX.REF MOL.CELL V. 30 507 2008REFN ISSN 1097-2765PMID 18498752DOI 10.1016/J.MOLCEL.2008.03.011 Variant Set Distributions Mapped Variants
General Structure Information 1inz EPN1 solution structure of the epsin n-terminal homology (enth) domain of human epsin -1.0Å AUTH S.KOSHIBA,T.KIGAWA,A.KIKUCHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE EPSIN N-TERMINALTITL 2 HOMOLOGY (ENTH) DOMAIN OF HUMAN EPSINREF J.STRUCT.FUNCT.GENOM. V. 2 1 2001REFN ISSN 1345-711XPMID 12836669DOI 10.1023/A:1011397007366 Variant Set Distributions Mapped Variants
General Structure Information 2eho GINS2 crystal structure of human gins complex 3.0Å AUTH J.M.CHOI,H.S.LIM,J.J.KIM,O.K.SONG,Y.CHOTITL CRYSTAL STRUCTURE OF THE HUMAN GINS COMPLEXREF GENES DEV. V. 21 1316 2007REFN ISSN 0890-9369PMID 17545466DOI 10.1101/GAD.1548107 Variant Set Distributions Mapped Variants
General Structure Information 2z0d ATG4B the crystal structure of human atg4b- lc3(1-120) complex 1.9Å AUTH K.SATOO,N.N.NODA,H.KUMETA,Y.FUJIOKA,N.MIZUSHIMA,AUTH 2 Y.OHSUMI,F.INAGAKITITL THE STRUCTURE OF ATG4B-LC3 COMPLEX REVEALS THETITL 2 MECHANISM OF LC3 PROCESSING AND DELIPIDATION DURINGTITL 3 AUTOPHAGY.REF EMBO J. V. 28 1341 2009REFN ISSN 0261-4189PMID 19322194DOI 10.1038/EMBOJ.2009.80 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2psx KLK5 crystal structure of human kallikrein 5 in complex with leupeptin 2.3Å AUTH M.DEBELA,P.GOETTIG,V.MAGDOLEN,R.HUBER,N.M.SCHECHTER,W.BODETITL STRUCTURAL BASIS OF THE ZINC INHIBITION OF HUMAN TISSUETITL 2 KALLIKREIN 5.REF J.MOL.BIOL. V. 373 1017 2007REFN ISSN 0022-2836PMID 17881000DOI 10.1016/J.JMB.2007.08.042 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3qe9 EXO1 crystal structure of human exonuclease 1 exo1 (d173a) in complex with dna (complex i) 2.51Å AUTH J.ORANS,E.A.MCSWEENEY,R.R.IYER,M.A.HAST,H.W.HELLINGA,AUTH 2 P.MODRICH,L.S.BEESETITL STRUCTURES OF HUMAN EXONUCLEASE 1 DNA COMPLEXES SUGGEST ATITL 2 UNIFIED MECHANISM FOR NUCLEASE FAMILY.REF CELL(CAMBRIDGE,MASS.) V. 145 212 2011REFN ISSN 0092-8674PMID 21496642DOI 10.1016/J.CELL.2011.03.005 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4i5l PPP2R3B structural mechanism of trimeric pp2a holoenzyme involving pr70: insight for cdc6 dephosphorylation 2.43Å AUTH N.WLODARCHAK,F.GUO,K.A.SATYSHUR,L.JIANG,P.D.JEFFREY,T.SUN,AUTH 2 V.STANEVICH,M.C.MUMBY,Y.XINGTITL STRUCTURE OF THE CA(2+)-DEPENDENT PP2A HETEROTRIMER ANDTITL 2 INSIGHTS INTO CDC6 DEPHOSPHORYLATION.REF CELL RES. V. 23 931 2013REFN ISSN 1001-0602PMID 23752926DOI 10.1038/CR.2013.77 Variant Set Distributions Mapped Variants
General Structure Information 3soa CAMK2A full-length human camkii 3.55Å AUTH L.H.CHAO,M.M.STRATTON,I.H.LEE,O.S.ROSENBERG,J.LEVITZ,AUTH 2 D.J.MANDELL,T.KORTEMME,J.T.GROVES,H.SCHULMAN,J.KURIYANTITL A MECHANISM FOR TUNABLE AUTOINHIBITION IN THE STRUCTURE OF ATITL 2 HUMAN CA(2+)/CALMODULIN- DEPENDENT KINASE II HOLOENZYME.REF CELL(CAMBRIDGE,MASS.) V. 146 732 2011REFN ISSN 0092-8674PMID 21884935DOI 10.1016/J.CELL.2011.07.038 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants