Assessment of Structural Intolerance and Durability
General Structure Information 3nbn NOTCH1 crystal structure of a dimer of notch transcription complex trimers on hes1 dna 3.45Å AUTH K.L.ARNETT,M.HASS,D.G.MCARTHUR,M.X.ILAGAN,J.C.ASTER,R.KOPAN,AUTH 2 S.C.BLACKLOWTITL STRUCTURAL AND MECHANISTIC INSIGHTS INTO COOPERATIVETITL 2 ASSEMBLY OF DIMERIC NOTCH TRANSCRIPTION COMPLEXES.REF NAT.STRUCT.MOL.BIOL. V. 17 1312 2010REFN ISSN 1545-9993PMID 20972443DOI 10.1038/NSMB.1938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 4m4r EPHA4 epha4 ectodomain complex with ephrin a5 3.13Å AUTH K.XU,D.TZVETKOVA-ROBEV,Y.XU,Y.GOLDGUR,Y.P.CHAN,J.P.HIMANEN,AUTH 2 D.B.NIKOLOVTITL INSIGHTS INTO EPH RECEPTOR TYROSINE KINASE ACTIVATION FROMTITL 2 CRYSTAL STRUCTURES OF THE EPHA4 ECTODOMAIN AND ITS COMPLEXTITL 3 WITH EPHRIN-A5.REF PROC.NATL.ACAD.SCI.USA V. 110 14634 2013REFN ISSN 0027-8424PMID 23959867DOI 10.1073/PNAS.1311000110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1ds6 ARHGDIB crystal structure of a rac-rhogdi complex 2.35Å AUTH K.SCHEFFZEK,I.STEPHAN,O.N.JENSEN,D.ILLENBERGER,AUTH 2 P.GIERSCHIKTITL THE RAC-RHOGDI COMPLEX AND THE STRUCTURAL BASISTITL 2 FOR THE REGULATION OF RHO PROTEINS BY RHOGDI.REF NAT.STRUCT.BIOL. V. 7 122 2000REFN ISSN 1072-8368PMID 10655614DOI 10.1038/72392 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2yho UBE2D1 the idol-ube2d complex mediates sterol-dependent degradation of the ldl receptor 2.1Å AUTH L.ZHANG,L.FAIRALL,B.T.GOULT,A.C.CALKIN,C.HONG,C.J.MILLARD,AUTH 2 P.TONTONOZ,J.W.SCHWABETITL THE IDOL-UBE2D COMPLEX MEDIATES STEROL-DEPENDENTTITL 2 DEGRADATION OF THE LDL RECEPTOR.REF GENES DEV. V. 25 1262 2011REFN ISSN 0890-9369PMID 21685362DOI 10.1101/GAD.2056211 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped […]
General Structure Information 2o8d MSH6 human mutsalpha (msh2/msh6) bound to adp and a g du mispair 3.0Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rv6 PGF crystal structure of plgf in complex with domain 2 of vegfr1 2.45Å AUTH H.W.CHRISTINGER,G.FUH,A.M.DE VOS,C.WIESMANNTITL THE CRYSTAL STRUCTURE OF PLACENTAL GROWTH FACTOR IN COMPLEXTITL 2 WITH DOMAIN 2 OF VASCULAR ENDOTHELIAL GROWTH FACTORTITL 3 RECEPTOR-1.REF J.BIOL.CHEM. V. 279 10382 2004REFN ISSN 0021-9258PMID 14684734DOI 10.1074/JBC.M313237200 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bcj CDK9 structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor 3.16Å AUTH A.J.HOLE,S.BAUMLI,H.SHAO,S.SHI,C.PEPPER,P.M.FISCHER,S.WANG,AUTH 2 J.A.ENDICOTT,M.E.M.NOBLETITL COMPARATIVE STRUCTURAL AND FUNCTIONAL STUDIES OFTITL 2 4-(THIAZOL- 5-YL)-2-(PHENYLAMINO)PYRIMIDINE-5-CARBONITRILETITL 3 CDK9 INHIBITORS SUGGEST THE BASIS FOR ISOTYPE SELECTIVITY.REF J.MED.CHEM. V. 56 660 2013REFN ISSN 0022-2623PMID 23252711DOI 10.1021/JM301495V Variant Set Distributions Mapped Variants
General Structure Information 2jri ATXN3 solution structure of the josephin domain of ataxin-3 in complex with ubiquitin molecule. -1.0Å AUTH G.NICASTRO,R.MENON,L.MASINO,A.PASTORETITL UNDERSTANDING THE PLASTICITY OF THETITL 2 UBIQUITIN-PROTEIN RECOGNITION CODE: THE JOSEPHINTITL 3 DOMAIN OF ATAXIN-3 IS A DIUBIQUITIN BINDING MOTIFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3v6o LEPR leptin receptor-antibody complex 1.95Å AUTH B.CARPENTER,G.R.HEMSWORTH,Z.WU,M.MAAMRA,C.J.STRASBURGER,AUTH 2 R.J.ROSS,P.J.ARTYMIUKTITL STRUCTURE OF THE HUMAN OBESITY RECEPTOR LEPTIN-BINDINGTITL 2 DOMAIN REVEALS THE MECHANISM OF LEPTIN ANTAGONISM BY ATITL 3 MONOCLONAL ANTIBODY.REF STRUCTURE V. 20 487 2012REFN ISSN 0969-2126PMID 22405007DOI 10.1016/J.STR.2012.01.019 Variant Set Distributions Mapped Variants