Assessment of Structural Intolerance and Durability
General Structure Information 3an2 CENPA the structure of the centromeric nucleosome containing cenp-a 3.6Å AUTH H.TACHIWANA,W.KAGAWA,T.SHIGA,A.OSAKABE,Y.MIYA,K.SAITO,AUTH 2 Y.HAYASHI-TAKANAKA,T.ODA,M.SATO,S.-Y.PARK,H.KIMURA,AUTH 3 H.KURUMIZAKATITL CRYSTAL STRUCTURE OF THE HUMAN CENTROMERIC NUCLEOSOMETITL 2 CONTAINING CENP-AREF NATURE V. 476 232 2011REFN ISSN 0028-0836PMID 21743476DOI 10.1038/NATURE10258 Variant Set Distributions Mapped Variants
General Structure Information 2ebv NUP153 solution structure of the third zf-ranbp domain from human nuclear pore complex protein nup153 -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD ZF-RANBP DOMAINTITL 2 FROM HUMAN NUCLEAR PORE COMPLEX PROTEIN NUP153REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ii6 LIG4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Ripley’s K […]
General Structure Information 1yr5 DAPK1 1.7-a structure of calmodulin bound to a peptide from dap kinase 1.7Å AUTH P.KURSULA,J.VAHOKOSKI,M.WILMANNSTITL RECOGNITION OF HUMAN DEATH-ASSOCIATED PROTEIN KINASES BYTITL 2 CALMODULINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2rd0 PIK3CA structure of a human p110alpha/p85alpha complex 3.05Å AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ua8 GRIA2 crystal structure analysis of a 6-amino quinazolinedione sulfonamide bound to human glur2 1.9Å AUTH D.ORAIN,S.OFNER,M.KOLLER,D.A.CARCACHE,W.FROESTL,H.ALLGEIER,AUTH 2 V.RASETTI,J.NOZULAK,H.MATTES,N.SOLDERMANN,P.FLOERSHEIM,AUTH 3 S.DESRAYAUD,J.KALLEN,K.LINGENHOEHL,S.URWYLERTITL 6-AMINO QUINAZOLINEDIONE SULFONAMIDES AS ORALLY ACTIVETITL 2 COMPETITIVE AMPA RECEPTOR ANTAGONISTS.REF BIOORG.MED.CHEM.LETT. V. 22 996 2012REFN ISSN 0960-894XPMID 22197388DOI 10.1016/J.BMCL.2011.12.009 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 3a8w PRKCI crystal structure of pkciota kinase domain 2.1Å AUTH T.TAKIMURA,K.KAMATA,K.FUKASAWA,H.OHSAWA,H.KOMATANI,AUTH 2 T.YOSHIZUMI,I.TAKAHASHI,H.KOTANI,Y.IWASAWATITL STRUCTURES OF THE PKC-IOTA KINASE DOMAIN IN ITS ATP-BOUNDTITL 2 AND APO FORMS REVEAL DEFINED STRUCTURES OF RESIDUES 533-551TITL 3 IN THE C-TERMINAL TAIL AND THEIR ROLES IN ATP BINDINGREF ACTA CRYSTALLOGR.,SECT.D V. 66 577 2010REFN ISSN 0907-4449PMID 20445233DOI […]
General Structure Information 4fu4 MMP13 human collagenase 3 (mmp-13) with peptide from pro-domain 2.85Å AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4fu4 MMP13 human collagenase 3 (mmp-13) with peptide from pro-domain 2.85Å AUTH E.A.STURA,R.VISSE,P.CUNIASSE,V.DIVE,H.NAGASETITL CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN COLLAGENASE 3TITL 2 (MMP-13) WITH PEPTIDES IN THE ACTIVE SITE DEFINES EXOSITESTITL 3 IN THE CATALYTIC DOMAIN.REF FASEB J. V. 27 4395 2013REFN ISSN 0892-6638PMID 23913860DOI 10.1096/FJ.13-233601 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3evs GDF5 crystal structure of the gdf-5:bmp receptor ib complex. 2.1Å AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants