General Structure Information
| PDB ID | 3a8w |
| HGNC Gene Label(s) | PRKCI |
| Structure Name | crystal structure of pkciota kinase domain |
| Resolution | 2.1Å |
| Reference | AUTH T.TAKIMURA,K.KAMATA,K.FUKASAWA,H.OHSAWA,H.KOMATANI,AUTH 2 T.YOSHIZUMI,I.TAKAHASHI,H.KOTANI,Y.IWASAWATITL STRUCTURES OF THE PKC-IOTA KINASE DOMAIN IN ITS ATP-BOUNDTITL 2 AND APO FORMS REVEAL DEFINED STRUCTURES OF RESIDUES 533-551TITL 3 IN THE C-TERMINAL TAIL AND THEIR ROLES IN ATP BINDINGREF ACTA CRYSTALLOGR.,SECT.D V. 66 577 2010REFN ISSN 0907-4449PMID 20445233DOI 10.1107/S0907444910005639 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 324 |
| Number Of SNVs | 41 |
| Number Of Permutations | 20843 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.038 |
| p-value | 0.392 |
COSMIC
| Number Of Residues | 324 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1528 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.238 |
| p-value | 0.433 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.12 |
| p-value | 0.816 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
