General Structure Information
| PDB ID | 3evs |
| HGNC Gene Label(s) | GDF5 |
| Structure Name | crystal structure of the gdf-5:bmp receptor ib complex. |
| Resolution | 2.1Å |
| Reference | AUTH A.KOTZSCH,J.NICKEL,A.SEHER,W.SEBALD,T.D.MULLERTITL CRYSTAL STRUCTURE ANALYSIS REVEALS A SPRING-LOADED LATCH ASTITL 2 MOLECULAR MECHANISM FOR GDF-5-TYPE I RECEPTOR SPECIFICITY.REF EMBO J. V. 28 937 2009REFN ISSN 0261-4189PMID 19229295DOI 10.1038/EMBOJ.2009.37 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 104 |
| Number Of SNVs | 16 |
| Number Of Permutations | 8716 |
| Optimal Distance Threshold | 14.0 |
| K Statistic | 0.225 |
| p-value | 0.637 |
ClinVar
| Number Of Residues | 104 |
| Number Of SNVs | 7 |
| Number Of Permutations | 3626 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.476 |
| p-value | 0.028 |
Ripley’s K Analysis Plots
ExACClinVar
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.36 |
| p-value | 0.006 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
