General Structure Information
| PDB ID | 2rd0 |
| HGNC Gene Label(s) | PIK3CA |
| Structure Name | structure of a human p110alpha/p85alpha complex |
| Resolution | 3.05Å |
| Reference | AUTH C.H.HUANG,D.MANDELKER,O.SCHMIDT-KITTLER,Y.SAMUELS,AUTH 2 V.E.VELCULESCU,K.W.KINZLER,B.VOGELSTEIN,S.B.GABELLI,AUTH 3 L.M.AMZELTITL THE STRUCTURE OF A HUMAN P110ALPHA/P85ALPHA COMPLEXTITL 2 ELUCIDATES THE EFFECTS OF ONCOGENIC PI3KALPHA MUTATIONS.REF SCIENCE V. 318 1744 2007REFN ISSN 0036-8075PMID 18079394DOI 10.1126/SCIENCE.1150799 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 984 |
| Number Of SNVs | 93 |
| Number Of Permutations | 34322 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.019 |
| p-value | 0.874 |
ClinVar
| Number Of Residues | 984 |
| Number Of SNVs | 8 |
| Number Of Permutations | 2512 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.071 |
| p-value | 0.116 |
COSMIC
| Number Of Residues | 984 |
| Number Of SNVs | 85 |
| Number Of Permutations | 8906 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.077 |
| p-value | 0.0 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.067 |
| p-value | 0.058 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 93 |
| Number Of COSMIC SNVs | 62 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.052 |
| p-value | 0.0 |
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:178916658 | L>F | A:15 | (88.41, 56.82, 116.76) | |
| 3:178916674 | L>V | A:21 | (103.08, 57.85, 117.81) | |
| 3:178916677 | V>I | A:22 | (103.07, 61.21, 114.11) | |
| 3:178916703 | rs372968114 | M>I | A:30 | (116.55, 63.02, 110.22) |
| 3:178916719 | C>R | A:36 | (100.00, 64.03, 118.40) | |
| 3:178916725 | COSM744 COSM87310 COSM40945 COSM1041447 COSM1041448 COSM1736101 |
R>C | A:38 | (91.51, 63.13, 117.45) |
| 3:178916740 | rs1051399 | I>V | A:43 | (99.49, 75.63, 113.18) |
| 3:178916753 | rs190372148 | H>R | A:47 | (105.51, 75.67, 117.05) |
| 3:178916754 | H>Q | A:47 | (105.51, 75.67, 117.05) | |
| 3:178916791 | rs71310379 | Q>K | A:60 | (122.37, 72.70, 110.59) |
| 3:178916802 | Q>H | A:63 | (114.25, 76.88, 105.63) | |
| 3:178916804 | D>G | A:64 | (112.07, 79.68, 108.03) | |
| 3:178916806 | COSM729832 COSM729831 |
E>K | A:65 | (107.61, 77.35, 110.85) |
| 3:178916886 | D>E | A:91 | (89.70, 65.95, 110.08) | |
| 3:178916954 | N>S | A:114 | (89.75, 74.81, 93.70) | |
| 3:178917486 | rs371727887 | I>V | A:121 | (83.56, 64.87, 94.06) |
| 3:178917489 | COSM1420761 COSM1420760 |
G>S | A:122 | (84.81, 61.83, 96.33) |
| 3:178917513 | M>V | A:130 | (95.56, 59.73, 84.75) | |
| 3:178917525 | COSM27491 COSM1420764 |
P>S | A:134 | (89.09, 60.59, 74.51) |
| 3:178917535 | COSM341932 COSM341931 |
Q>R | A:137 | (89.96, 64.48, 79.11) |
| 3:178917554 | I>M | A:143 | (81.10, 71.30, 79.83) | |
| 3:178917561 | V>I | A:146 | (77.68, 75.79, 80.34) | |
| 3:178917591 | rs201705993 | L>V | A:156 | (74.93, 89.91, 83.09) |
| 3:178917600 | P>S | A:159 | (73.94, 93.07, 92.24) | |
| 3:178917609 | R>G | A:162 | (75.94, 87.76, 92.97) | |
| 3:178917618 | Y>H | A:165 | (73.03, 81.46, 91.95) | |
| 3:178917625 | Y>C | A:167 | (69.41, 83.95, 98.64) | |
| 3:178917642 | S>A | A:173 | (53.73, 77.61, 88.90) | |
| 3:178917648 | P>A | A:175 | (49.28, 82.50, 89.16) | |
| 3:178917673 | N>S | A:183 | (37.18, 80.85, 100.42) | |
| 3:178919101 | rs541134560 | V>I | A:196 | (61.99, 96.74, 111.48) |
| 3:178919106 | I>M | A:197 | (65.82, 95.12, 113.45) | |
| 3:178919113 | P>A | A:200 | (72.43, 98.36, 118.74) | |
| 3:178919138 | rs372610277 | T>S | A:208 | (50.05, 94.82, 111.10) |
| 3:178919150 | N>S | A:212 | (45.74, 92.73, 98.10) | |
| 3:178919303 | E>G | A:263 | (60.48, 88.34, 91.15) | |
| 3:178919307 | K>N | A:264 | (58.36, 91.91, 90.45) | |
| 3:178919311 | P>S | A:266 | (51.79, 87.31, 93.22) | |
| 3:178921335 | I>V | A:273 | (52.39, 83.35, 101.80) | |
| 3:178921342 | S>N | A:275 | (51.67, 77.75, 104.04) | |
| 3:178921428 | M>V | A:304 | (89.30, 77.11, 82.43) | |
| 3:178921516 | A>V | A:333 | (76.05, 42.46, 56.48) | |
| 3:178921558 | N>I | A:347 | (83.26, 22.33, 86.38) | |
| 3:178922319 | COSM1579089 COSM1579088 |
G>V | A:363 | (66.22, 49.56, 73.18) |
| 3:178922326 | COSM1420800 COSM1420799 |
E>D | A:365 | (63.78, 43.70, 69.70) |
| 3:178922339 | N>H | A:370 | (73.24, 35.25, 67.06) | |
| 3:178922361 | rs113613074 | P>R | A:377 | (81.46, 23.80, 78.91) |
| 3:178922370 | rs202013300 COSM4115414 COSM4115413 |
N>S | A:380 | (90.43, 28.06, 78.69) |
| 3:178922371 | N>K | A:380 | (90.43, 28.06, 78.69) | |
| 3:178927410 | rs3729680 | I>M | A:391 | (70.72, 44.46, 59.68) |
| 3:178927412 | Y>C | A:392 | (71.71, 46.32, 54.18) | |
| 3:178927426 | P>A | A:397 | (70.22, 53.01, 64.13) | |
| 3:178927430 | COSM1484863 COSM1484862 |
R>H | A:398 | (73.76, 57.66, 66.37) |
| 3:178928002 | I>K | A:427 | (78.94, 48.03, 72.92) | |
| 3:178928019 | T>A | A:433 | (82.64, 61.07, 66.95) | |
| 3:178928026 | T>I | A:435 | (82.67, 56.86, 64.37) | |
| 3:178928044 | M>T | A:441 | (86.66, 46.33, 71.89) | |
| 3:178928046 | rs200951754 | A>P | A:442 | (87.97, 44.96, 75.36) |
| 3:178928058 | W>R | A:446 | (79.04, 45.62, 84.18) | |
| 3:178928222 | T>S | A:470 | (86.31, 40.53, 85.80) | |
| 3:178928246 | D>Y | A:478 | (83.75, 44.63, 60.03) | |
| 3:178928252 | rs186076493 | F>L | A:480 | (84.52, 48.78, 56.02) |
| 3:178928285 | V>M | A:491 | (69.33, 62.89, 56.66) | |
| 3:178928303 | rs199563773 | N>H | A:497 | (61.64, 58.15, 50.32) |
| 3:178928304 | COSM249878 | N>S | A:497 | (61.64, 58.15, 50.32) |
| 3:178928306 | rs376198913 | W>R | A:498 | (58.74, 62.54, 52.06) |
| 3:178928315 | S>T | A:501 | (53.72, 57.60, 44.35) | |
| 3:178936091 | rs104886003 | E>K | A:545 | (52.62, 44.96, 65.41) |
| 3:178937008 | E>D | A:563 | (49.54, 64.86, 72.04) | |
| 3:178937049 | R>K | A:577 | (68.33, 53.21, 55.17) | |
| 3:178937389 | rs200694869 | I>V | A:593 | (55.10, 68.50, 73.99) |
| 3:178937436 | D>E | A:608 | (67.61, 59.17, 68.90) | |
| 3:178937440 | M>V | A:610 | (67.41, 63.80, 66.83) | |
| 3:178937461 | COSM1041502 COSM1041501 |
R>W | A:617 | (64.58, 71.35, 71.66) |
| 3:178937482 | T>A | A:624 | (59.35, 76.02, 85.38) | |
| 3:178937504 | Y>C | A:631 | (59.11, 66.78, 87.81) | |
| 3:178937509 | I>L | A:633 | (64.97, 62.58, 91.23) | |
| 3:178938796 | V>I | A:680 | (77.23, 56.06, 87.50) | |
| 3:178938838 | rs200404201 | A>S | A:694 | (81.06, 77.08, 88.81) |
| 3:178941877 | COSM1420894 COSM1420893 |
M>I | A:732 | (74.00, 58.35, 124.75) |
| 3:178941879 | rs181194055 | K>R | A:733 | (78.13, 58.40, 128.14) |
| 3:178941888 | V>A | A:736 | (77.98, 63.11, 124.42) | |
| 3:178941901 | R>S | A:740 | (80.79, 67.29, 124.80) | |
| 3:178941903 | R>Q | A:741 | (86.69, 64.52, 120.83) | |
| 3:178941920 | A>T | A:747 | (81.86, 70.02, 111.81) | |
| 3:178942502 | R>Q | A:770 | (67.64, 62.03, 121.50) | |
| 3:178943756 | R>Q | A:808 | (67.45, 54.65, 96.57) | |
| 3:178943786 | rs371049193 | R>H | A:818 | (55.79, 66.08, 97.49) |
| 3:178947094 | C>R | A:844 | (72.37, 53.29, 102.69) | |
| 3:178947805 | I>V | A:894 | (37.42, 65.74, 112.87) | |
| 3:178947901 | D>N | A:926 | (46.83, 69.55, 113.98) | |
| 3:178948154 | E>K | A:976 | (30.43, 62.85, 109.17) | |
| 3:178951904 | COSM27351 | A>S | A:987 | (41.07, 61.27, 94.57) |
| 3:178951905 | A>V | A:987 | (41.07, 61.27, 94.57) | |
| 3:178951926 | rs373295359 | H>R | A:994 | (46.47, 63.71, 86.19) |
| 3:178951970 | COSM1420942 COSM1420944 COSM1420941 COSM1420943 |
G>R | A:1009 | (68.57, 49.77, 91.43) |
| 3:178952080 | D>E | A:1045 | (36.89, 42.99, 99.15) |
[+] ClinVar Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:178916948 | rs863225460 | I>N | A:112 | (96.35, 72.91, 94.49) |
| 3:178922364 | rs397514565 | C>Y | A:378 | (84.74, 25.31, 81.26) |
| 3:178936082 | rs121913273 | E>K | A:542 | (52.17, 46.96, 75.06) |
| 3:178936091 | rs104886003 | E>K | A:545 | (52.62, 44.96, 65.41) |
| 3:178936092 | rs121913274 | E>A | A:545 | (52.62, 44.96, 65.41) |
| 3:178936093 | rs121913275 | E>D | A:545 | (52.62, 44.96, 65.41) |
| 3:178936094 | rs121913286 | Q>K | A:546 | (47.67, 45.44, 64.05) |
| 3:178936095 | rs397517201 | Q>R | A:546 | (47.67, 45.44, 64.05) |
| 3:178952018 | rs397517202 | T>A | A:1025 | (45.53, 50.09, 90.88) |
| 3:178952074 | rs121913283 | M>I | A:1043 | (36.33, 50.00, 100.31) |
| 3:178952084 | rs121913281 | H>Y | A:1047 | (37.16, 47.94, 104.89) |
| 3:178952085 | rs121913279 | H>L | A:1047 | (37.16, 47.94, 104.89) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 3:178916648 | COSM4998504 | G>V | A:12 | (91.18, 50.48, 109.97) |
| 3:178916706 | COSM27376 | I>M | A:31 | (112.25, 59.88, 111.08) |
| 3:178916725 | COSM1041448 | R>C | A:38 | (91.51, 63.13, 117.45) |
| 3:178916726 | COSM1041449 | R>H | A:38 | (91.51, 63.13, 117.45) |
| 3:178916728 | COSM1041450 | E>K | A:39 | (92.06, 66.81, 118.81) |
| 3:178916836 | COSM1566579 | Q>K | A:75 | (92.15, 56.49, 103.52) |
| 3:178916854 | COSM271871 | E>K | A:81 | (100.43, 69.69, 98.84) |
| 3:178916876 | COSM746 | R>Q | A:88 | (91.27, 69.84, 113.87) |
| 3:178916882 | COSM1753025 | C>S | A:90 | (91.24, 63.78, 112.69) |
| 3:178916890 | COSM1041455 | R>W | A:93 | (91.12, 62.51, 104.14) |
| 3:178916891 | COSM1041456 | R>Q | A:93 | (91.12, 62.51, 104.14) |
| 3:178916924 | COSM163485 | P>L | A:104 | (105.63, 75.37, 98.45) |
| 3:178916929 | COSM271872 | G>R | A:106 | (103.23, 74.85, 92.25) |
| 3:178916930 | COSM166339 | G>A | A:106 | (103.23, 74.85, 92.25) |
| 3:178916936 | COSM342716 | R>H | A:108 | (99.14, 77.89, 89.82) |
| 3:178916941 | COSM6145 | E>K | A:110 | (95.30, 80.24, 95.27) |
| 3:178916945 | COSM1420751 | K>R | A:111 | (95.49, 75.27, 90.57) |
| 3:178916946 | COSM1041464 | K>N | A:111 | (95.49, 75.27, 90.57) |
| 3:178916957 | COSM125368 | R>L | A:115 | (92.12, 71.05, 91.65) |
| 3:178917490 | COSM479738 | G>D | A:122 | (84.81, 61.83, 96.33) |
| 3:178917525 | COSM1420764 | P>S | A:134 | (89.09, 60.59, 74.51) |
| 3:178917661 | COSM1420773 | K>R | A:179 | (38.64, 78.46, 93.84) |
| 3:178921540 | COSM1420785 | A>V | A:341 | (86.47, 34.71, 77.40) |
| 3:178921548 | COSM253279 | V>M | A:344 | (84.02, 31.54, 84.13) |
| 3:178921549 | COSM258749 | V>G | A:344 | (84.02, 31.54, 84.13) |
| 3:178921552 | COSM94978 | N>I | A:345 | (82.02, 30.52, 87.54) |
| 3:178921553 | COSM132748 | N>K | A:345 | (82.02, 30.52, 87.54) |
| 3:178921566 | COSM755 | D>H | A:350 | (73.90, 18.14, 83.28) |
| 3:178921567 | COSM271785 | D>G | A:350 | (73.90, 18.14, 83.28) |
| 3:178922301 | COSM276752 | R>Q | A:357 | (71.83, 35.70, 73.34) |
| 3:178922321 | COSM1041476 | G>R | A:364 | (64.23, 47.32, 71.43) |
| 3:178922324 | COSM86044 | E>K | A:365 | (63.78, 43.70, 69.70) |
| 3:178922328 | COSM446004 | P>R | A:366 | (66.76, 45.44, 66.23) |
| 3:178922363 | COSM756 | C>R | A:378 | (84.74, 25.31, 81.26) |
| 3:178922364 | COSM1041478 | C>Y | A:378 | (84.74, 25.31, 81.26) |
| 3:178927410 | COSM5019247 | I>M | A:391 | (70.72, 44.46, 59.68) |
| 3:178927450 | COSM1420804 | S>P | A:405 | (75.43, 37.58, 77.44) |
| 3:178927458 | COSM5025090 | C>W | A:407 | (74.34, 33.12, 80.80) |
| 3:178927462 | COSM5030947 | V>L | A:409 | (69.61, 27.30, 80.98) |
| 3:178928079 | COSM758 | E>Q | A:453 | (69.10, 34.28, 83.22) |
| 3:178928081 | COSM3408454 | E>D | A:453 | (69.10, 34.28, 83.22) |
| 3:178928091 | COSM1420825 | N>D | A:457 | (70.32, 43.49, 80.29) |
| 3:178928092 | COSM1420828 | N>S | A:457 | (70.32, 43.49, 80.29) |
| 3:178928225 | COSM1308840 | P>A | A:471 | (84.73, 38.67, 83.29) |
| 3:178928226 | COSM136387 | P>L | A:471 | (84.73, 38.67, 83.29) |
| 3:178928291 | COSM1757081 | E>K | A:493 | (68.67, 64.97, 50.62) |
| 3:178928304 | COSM5025057 | N>S | A:497 | (61.64, 58.15, 50.32) |
| 3:178936047 | COSM33701 | Q>R | A:530 | (37.19, 57.79, 65.41) |
| 3:178936050 | COSM41784 | L>P | A:531 | (42.37, 56.26, 65.66) |
| 3:178936070 | COSM1716811 | D>Y | A:538 | (49.00, 53.89, 79.29) |
| 3:178936073 | COSM249880 | P>S | A:539 | (52.83, 54.80, 78.25) |
| 3:178936074 | COSM759 | P>R | A:539 | (52.83, 54.80, 78.25) |
| 3:178936082 | COSM760 | E>K | A:542 | (52.17, 46.96, 75.06) |
| 3:178936083 | COSM1041495 | E>A | A:542 | (52.17, 46.96, 75.06) |
| 3:178936085 | COSM25083 | I>V | A:543 | (50.89, 49.26, 70.61) |
| 3:178936089 | COSM249876 | T>I | A:544 | (48.91, 46.33, 67.86) |
| 3:178936091 | COSM763 | E>K | A:545 | (52.62, 44.96, 65.41) |
| 3:178936092 | COSM12458 | E>A | A:545 | (52.62, 44.96, 65.41) |
| 3:178936093 | COSM327064 | E>D | A:545 | (52.62, 44.96, 65.41) |
| 3:178936094 | COSM6147 | Q>E | A:546 | (47.67, 45.44, 64.05) |
| 3:178936095 | COSM1757082 | Q>L | A:546 | (47.67, 45.44, 64.05) |
| 3:178936096 | COSM3205634 | Q>H | A:546 | (47.67, 45.44, 64.05) |
| 3:178936098 | COSM1420864 | E>G | A:547 | (47.70, 49.99, 66.50) |
| 3:178936103 | COSM17470 | D>N | A:549 | (51.49, 49.63, 60.17) |
| 3:178936112 | COSM21463 | W>G | A:552 | (55.34, 55.49, 59.45) |
| 3:178937019 | COSM30790 | K>R | A:567 | (52.22, 56.31, 71.08) |
| 3:178937392 | COSM87304 | K>E | A:594 | (53.00, 68.87, 79.23) |
| 3:178937410 | COSM1537052 | E>K | A:600 | (57.51, 59.31, 77.44) |
| 3:178937422 | COSM1041499 | C>R | A:604 | (64.95, 53.52, 78.00) |
| 3:178937738 | COSM250052 | V>A | A:638 | (67.41, 59.89, 82.47) |
| 3:178937806 | COSM768 | Q>K | A:661 | (72.38, 78.11, 94.83) |
| 3:178937825 | COSM1420880 | F>S | A:667 | (72.75, 68.59, 90.06) |
| 3:178938787 | COSM1617226 | N>D | A:677 | (77.22, 53.07, 91.36) |
| 3:178938860 | COSM1666842 | H>P | A:701 | (78.35, 77.16, 102.05) |
| 3:178938932 | COSM1420886 | D>G | A:725 | (76.48, 46.08, 119.85) |
| 3:178938934 | COSM87306 | E>K | A:726 | (77.84, 48.04, 124.71) |
| 3:178938935 | COSM1420889 | E>A | A:726 | (77.84, 48.04, 124.71) |
| 3:178941879 | COSM1566569 | K>R | A:733 | (78.13, 58.40, 128.14) |
| 3:178943785 | COSM1041508 | R>C | A:818 | (55.79, 66.08, 97.49) |
| 3:178947161 | COSM87311 | L>W | A:866 | (43.54, 50.49, 132.71) |
| 3:178947827 | COSM769 | C>F | A:901 | (42.72, 59.71, 106.02) |
| 3:178947850 | COSM770 | F>L | A:909 | (44.77, 51.08, 96.23) |
| 3:178948044 | COSM1041513 | D>G | A:939 | (52.93, 44.93, 96.11) |
| 3:178948136 | COSM94980 | E>K | A:970 | (28.62, 49.54, 112.99) |
| 3:178951889 | COSM28546 | E>K | A:982 | (33.09, 62.71, 97.43) |
| 3:178951890 | COSM1420913 | E>G | A:982 | (33.09, 62.71, 97.43) |
| 3:178951901 | COSM1420917 | K>E | A:986 | (36.18, 63.41, 93.50) |
| 3:178951902 | COSM1420918 | K>R | A:986 | (36.18, 63.41, 93.50) |
| 3:178951903 | COSM87305 | K>N | A:986 | (36.18, 63.41, 93.50) |
| 3:178951910 | COSM3846793 | L>V | A:989 | (38.58, 60.11, 89.27) |
| 3:178951920 | COSM1041515 | R>P | A:992 | (41.91, 57.07, 85.95) |
| 3:178951946 | COSM29095 | L>I | A:1001 | (57.74, 60.00, 87.23) |
| 3:178951952 | COSM328020 | S>P | A:1003 | (59.69, 54.89, 83.95) |
| 3:178951957 | COSM1041516 | M>I | A:1004 | (62.11, 58.80, 84.29) |
| 3:178951958 | COSM3974287 | M>V | A:1005 | (63.47, 56.12, 88.68) |
| 3:178951964 | COSM94982 | G>R | A:1007 | (68.29, 53.20, 86.49) |
| 3:178951965 | COSM25082 | G>D | A:1007 | (68.29, 53.20, 86.49) |
| 3:178951967 | COSM779 | S>P | A:1008 | (67.60, 52.81, 89.67) |
| 3:178951968 | COSM249141 | S>C | A:1008 | (67.60, 52.81, 89.67) |
| 3:178951971 | COSM28544 | G>E | A:1009 | (68.57, 49.77, 91.43) |
| 3:178951976 | COSM1420947 | P>S | A:1011 | (65.02, 46.33, 94.06) |
| 3:178951977 | COSM328027 | P>L | A:1011 | (65.02, 46.33, 94.06) |
| 3:178951979 | COSM307758 | E>K | A:1012 | (61.96, 48.00, 94.58) |
| 3:178951980 | COSM1420951 | E>G | A:1012 | (61.96, 48.00, 94.58) |
| 3:178951988 | COSM303946 | S>P | A:1015 | (60.68, 46.56, 84.62) |
| 3:178951989 | COSM21464 | S>F | A:1015 | (60.68, 46.56, 84.62) |
| 3:178951991 | COSM33600 | F>L | A:1016 | (58.69, 49.59, 81.64) |
| 3:178951994 | COSM27377 | D>H | A:1017 | (56.83, 44.32, 84.51) |
| 3:178951995 | COSM1420958 | D>G | A:1017 | (56.83, 44.32, 84.51) |
| 3:178951997 | COSM33599 | D>N | A:1018 | (57.51, 46.31, 88.20) |
| 3:178952000 | COSM33959 | I>F | A:1019 | (55.37, 50.39, 86.11) |
| 3:178952004 | COSM28938 | A>V | A:1020 | (51.97, 47.33, 86.04) |
| 3:178952006 | COSM246589 | Y>H | A:1021 | (50.31, 47.04, 91.52) |
| 3:178952007 | COSM276755 | Y>C | A:1021 | (50.31, 47.04, 91.52) |
| 3:178952013 | COSM1420972 | R>L | A:1023 | (47.89, 49.28, 83.57) |
| 3:178952016 | COSM1420973 | K>R | A:1024 | (46.14, 46.28, 88.30) |
| 3:178952018 | COSM12590 | T>S | A:1025 | (45.53, 50.09, 90.88) |
| 3:178952019 | COSM1666840 | T>I | A:1025 | (45.53, 50.09, 90.88) |
| 3:178952030 | COSM1041521 | D>H | A:1029 | (40.31, 48.66, 79.66) |
| 3:178952037 | COSM3726797 | T>I | A:1031 | (35.57, 53.72, 81.80) |
| 3:178952046 | COSM12462 | E>G | A:1034 | (33.81, 50.73, 84.26) |
| 3:178952048 | COSM27375 | A>T | A:1035 | (36.99, 52.11, 87.76) |
| 3:178952049 | COSM17445 | A>V | A:1035 | (36.99, 52.11, 87.76) |
| 3:178952052 | COSM1420984 | L>S | A:1036 | (34.57, 54.55, 90.47) |
| 3:178952054 | COSM30627 | E>K | A:1037 | (32.23, 50.59, 89.96) |
| 3:178952055 | COSM328026 | E>G | A:1037 | (32.23, 50.59, 89.96) |
| 3:178952060 | COSM1420989 | F>L | A:1039 | (38.42, 52.29, 94.97) |
| 3:178952063 | COSM86043 | M>L | A:1040 | (33.63, 50.61, 95.59) |
| 3:178952064 | COSM163486 | M>T | A:1040 | (33.63, 50.61, 95.59) |
| 3:178952065 | COSM25085 | M>I | A:1040 | (33.63, 50.61, 95.59) |
| 3:178952068 | COSM28545 | K>N | A:1041 | (35.19, 45.72, 93.54) |
| 3:178952072 | COSM12591 | M>V | A:1043 | (36.33, 50.00, 100.31) |
| 3:178952073 | COSM12463 | M>T | A:1043 | (36.33, 50.00, 100.31) |
| 3:178952074 | COSM94985 | M>I | A:1043 | (36.33, 50.00, 100.31) |
| 3:178952075 | COSM27134 | N>D | A:1044 | (33.67, 46.01, 100.36) |
| 3:178952076 | COSM1421001 | N>S | A:1044 | (33.67, 46.01, 100.36) |
| 3:178952077 | COSM12592 | N>K | A:1044 | (33.67, 46.01, 100.36) |
| 3:178952078 | COSM1421002 | D>N | A:1045 | (36.89, 42.99, 99.15) |
| 3:178952081 | COSM27273 | A>T | A:1046 | (39.12, 45.06, 103.01) |
| 3:178952082 | COSM6146 | A>V | A:1046 | (39.12, 45.06, 103.01) |
| 3:178952084 | COSM1041523 | H>Y | A:1047 | (37.16, 47.94, 104.89) |
| 3:178952085 | COSM94986 | H>R | A:1047 | (37.16, 47.94, 104.89) |
| 3:178952086 | COSM1041524 | H>Q | A:1047 | (37.16, 47.94, 104.89) |
| 3:178952087 | COSM1421011 | H>N | A:1048 | (34.91, 42.67, 105.83) |
| 3:178952088 | COSM3734761 | H>L | A:1048 | (34.91, 42.67, 105.83) |
| 3:178952090 | COSM1421012 | G>S | A:1049 | (31.88, 47.28, 104.10) |
| 3:178952091 | COSM27158 | G>A | A:1049 | (31.88, 47.28, 104.10) |
| 3:178952093 | COSM249882 | G>S | A:1050 | (30.99, 49.42, 101.54) |
| 3:178952094 | COSM17446 | G>D | A:1050 | (30.99, 49.42, 101.54) |