Assessment of Structural Intolerance and Durability
General Structure Information 3uio RANBP2 complex between human rangap1-sumo2, ubc9 and the ir1 domain from ranbp2 containing ir2 motif ii 2.6Å AUTH J.R.GAREAU,D.REVERTER,C.D.LIMATITL DETERMINANTS OF SMALL UBIQUITIN-LIKE MODIFIER 1 (SUMO1)TITL 2 PROTEIN SPECIFICITY, E3 LIGASE, AND SUMO-RANGAP1 BINDINGTITL 3 ACTIVITIES OF NUCLEOPORIN RANBP2.REF J.BIOL.CHEM. V. 287 4740 2012REFN ISSN 0021-9258PMID 22194619DOI 10.1074/JBC.M111.321141 Variant Set Distributions […]
General Structure Information 2fu5 RABIF structure of rab8 in complex with mss4 2.0Å AUTH A.ITZEN,O.PYLYPENKO,R.S.GOODY,K.ALEXANDROV,A.RAKTITL NUCLEOTIDE EXCHANGE VIA LOCAL PROTEINTITL 2 UNFOLDING-STRUCTURE OF RAB8 IN COMPLEX WITH MSS4REF EMBO J. V. 25 1445 2006REFN ISSN 0261-4189PMID 16541104DOI 10.1038/SJ.EMBOJ.7601044 Variant Set Distributions Mapped Variants
General Structure Information 3t1i MRE11A crystal structure of human mre11: understanding tumorigenic mutations 3.0Å AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2h11 TPMT amino-terminal truncated thiopurine s-methyltransferase complexed with s-adenosyl-l-homocysteine 1.89Å AUTH J.R.HORTON,X.CHENGTITL AMINO-TERMINAL TRUNCATED THIOPURINETITL 2 S-METHYLTRANSFERASE COMPLEXED WITHTITL 3 S-ADENOSYL-L-HOMOCYSTEINEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3s9d IFNAR2 binary complex between ifna2 and ifnar2 2.0Å AUTH C.THOMAS,I.MORAGA,D.LEVIN,P.O.KRUTZIK,Y.PODOPLELOVA,A.TREJO,AUTH 2 C.LEE,G.YARDEN,S.E.VLECK,J.S.GLENN,G.P.NOLAN,J.PIEHLER,AUTH 3 G.SCHREIBER,K.C.GARCIATITL STRUCTURAL LINKAGE BETWEEN LIGAND DISCRIMINATION ANDTITL 2 RECEPTOR ACTIVATION BY TYPE I INTERFERONS.REF CELL(CAMBRIDGE,MASS.) V. 146 621 2011REFN ISSN 0092-8674PMID 21854986DOI 10.1016/J.CELL.2011.06.048 Variant Set Distributions Mapped Variants
General Structure Information 4kbc CSNK1D ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor 1.98Å AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2aot HNMT histamine methyltransferase complexed with the antihistamine drug diphenhydramine 1.9Å AUTH J.R.HORTON,K.SAWADA,M.NISHIBORI,X.CHENGTITL STRUCTURAL BASIS FOR INHIBITION OF HISTAMINETITL 2 N-METHYLTRANSFERASE BY DIVERSE DRUGSREF J.MOL.BIOL. V. 353 334 2005REFN ISSN 0022-2836PMID 16168438DOI 10.1016/J.JMB.2005.08.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3fey KPNA2 crystal structure of the cbc-importin alpha complex. 2.2Å AUTH S.M.DIAS,K.F.WILSON,K.S.ROJAS,A.L.AMBROSIO,R.A.CERIONETITL THE MOLECULAR BASIS FOR THE REGULATION OF THE CAP-BINDINGTITL 2 COMPLEX BY THE IMPORTINS.REF NAT.STRUCT.MOL.BIOL. V. 16 930 2009REFN ISSN 1545-9993PMID 19668212DOI 10.1038/NSMB.1649 Variant Set Distributions Mapped Variants
General Structure Information 2zks GZMM structural insights into the proteolytic machinery of apoptosis- inducing granzyme m 2.7Å AUTH L.WU,L.WANG,G.HUA,K.LIU,X.YANG,Y.ZHAI,M.BARTLAM,F.SUN,Z.FANTITL STRUCTURAL BASIS FOR PROTEOLYTIC SPECIFICITY OF THE HUMANTITL 2 APOPTOSIS-INDUCING GRANZYME MREF J.IMMUNOL. V. 183 421 2009REFN ISSN 0022-1767PMID 19542453DOI 10.4049/JIMMUNOL.0803088 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4ja8 IDH2 complex of mitochondrial isocitrate dehydrogenase r140q mutant with agi-6780 inhibitor 1.55Å AUTH F.WANG,J.TRAVINS,B.DELABARRE,V.PENARD-LACRONIQUE,S.SCHALM,AUTH 2 E.HANSEN,K.STRALEY,A.KERNYTSKY,W.LIU,C.GLISER,H.YANG,AUTH 3 S.GROSS,E.ARTIN,V.SAADA,E.MYLONAS,C.QUIVORON,AUTH 4 J.POPOVICI-MULLER,J.O.SAUNDERS,F.G.SALITURO,S.YAN,S.MURRAY,AUTH 5 W.WEI,Y.GAO,L.DANG,M.DORSCH,S.AGRESTA,D.P.SCHENKEIN,AUTH 6 S.A.BILLER,S.M.SU,S.DE BOTTON,K.E.YENTITL TARGETED INHIBITION OF MUTANT IDH2 IN LEUKEMIA CELLS INDUCESTITL 2 CELLULAR DIFFERENTIATION.REF SCIENCE V. 340 622 2013REFN ISSN 0036-8075PMID 23558173DOI 10.1126/SCIENCE.1234769 Variant Set Distributions Ripley’s K […]