General Structure Information
| PDB ID | 4kbc |
| HGNC Gene Label(s) | CSNK1D |
| Structure Name | ck1d in complex with {4-[3-(4-fluorophenyl)-1h-pyrazol-4-yl]pyridin-2- yl}methanol inhibitor |
| Resolution | 1.98Å |
| Reference | AUTH S.MENTE,E.ARNOLD,T.BUTLER,S.CHAKRAPANI,R.CHANDRASEKARAN,AUTH 2 K.CHERRY,K.DIRICO,A.DORAN,K.FISHER,P.GALATSIS,M.GREEN,AUTH 3 M.HAYWARD,J.HUMPHREY,J.KNAFELS,J.LI,S.LIU,M.MARCONI,AUTH 4 S.MCDONALD,J.OHREN,V.PARADIS,B.SNEED,K.WALTON,T.WAGERTITL LIGAND-PROTEIN INTERACTIONS OF SELECTIVE CASEIN KINASE 1TITL 2 DELTA INHIBITORS.REF J.MED.CHEM. V. 56 6819 2013REFN ISSN 0022-2623PMID 23919824DOI 10.1021/JM4006324 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 288 |
| Number Of SNVs | 34 |
| Number Of Permutations | 17015 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.112 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 288 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1597 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.167 |
| p-value | 0.863 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 34 |
| Number Of COSMIC SNVs | 8 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | 0.222 |
| p-value | 0.581 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
