General Structure Information
| PDB ID | 3t1i |
| HGNC Gene Label(s) | MRE11A |
| Structure Name | crystal structure of human mre11: understanding tumorigenic mutations |
| Resolution | 3.0Å |
| Reference | AUTH Y.B.PARK,J.CHAE,Y.KIM,Y.CHOTITL CRYSTAL STRUCTURE OF HUMAN MRE11: UNDERSTANDING TUMORIGENICTITL 2 MUTATIONSREF STRUCTURE V. 19 1591 2011REFN ISSN 0969-2126PMID 22078559DOI 10.1016/J.STR.2011.09.010 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 368 |
| Number Of SNVs | 99 |
| Number Of Permutations | 61840 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.205 |
| p-value | 0.096 |
ClinVar
| Number Of Residues | 368 |
| Number Of SNVs | 5 |
| Number Of Permutations | 2026 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.1 |
| p-value | 0.924 |
COSMIC
| Number Of Residues | 368 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1430 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.179 |
| p-value | 0.712 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 99 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.135 |
| p-value | 0.828 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 99 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.408 |
| p-value | 0.443 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
