Assessment of Structural Intolerance and Durability
General Structure Information 3pjc JAK3 crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family 2.2Å AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q […]
General Structure Information 4n3b HCFC1 crystal structure of human o-glcnac transferase bound to a peptide from hcf-1 pro-repeat2(1-26)e10q and udp-5sglcnac 2.17Å AUTH M.B.LAZARUS,J.JIANG,V.KAPURIA,T.BHUIYAN,J.JANETZKO,AUTH 2 W.F.ZANDBERG,D.J.VOCADLO,W.HERR,S.WALKERTITL HCF-1 IS CLEAVED IN THE ACTIVE SITE OF O-GLCNAC TRANSFERASE.REF SCIENCE V. 342 1235 2013REFN ISSN 0036-8075PMID 24311690DOI 10.1126/SCIENCE.1243990 Variant Set Distributions Mapped Variants
General Structure Information 4b18 KPNA1 the crystal structure of human importin alpha 5 with tert nls peptide 2.52Å AUTH S.A.JEONG,K.KIM,J.H.LEE,J.S.CHA,P.KHADKA,H.CHO,I.K.CHUNGTITL AKT-MEDIATED PHOSPHORYLATION INCREASES THE BINDING AFFINITYTITL 2 OF HTERT FOR IMPORTIN ALPHA TO PROMOTE NUCLEARTITL 3 TRANSLOCATION.REF J.CELL.SCI. V. 128 2287 2015REFN ISSN 0021-9533PMID 25999477DOI 10.1242/JCS.166132 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2kg1 HNRNPF structure of the third qrrm domain of hnrnp f in complex with a agggau g-tract rna -1.0Å AUTH C.DOMINGUEZ,J.F.FISETTE,B.CHABOT,F.H.ALLAINTITL STRUCTURAL BASIS OF G-TRACT RECOGNITION AND ENCAGING BYTITL 2 HNRNP F QUASI-RRMS.REF NAT.STRUCT.MOL.BIOL. V. 17 853 2010REFN ISSN 1545-9993PMID 20526337DOI 10.1038/NSMB.1814 Variant Set Distributions Mapped Variants
General Structure Information 1nvp GTF2A1 human tfiia/tbp/dna complex 2.1Å AUTH M.BLEICHENBACHER,S.TAN,T.J.RICHMONDTITL NOVEL INTERACTIONS BETWEEN THE COMPONENTS OF HUMANTITL 2 AND YEAST TFIIA/TBP/DNA COMPLEXES.REF J.MOL.BIOL. V. 332 783 2003REFN ISSN 0022-2836PMID 12972251DOI 10.1016/S0022-2836(03)00887-8 Variant Set Distributions Mapped Variants
General Structure Information 1rrp RANBP2 structure of the ran-gppnhp-ranbd1 complex 2.96Å AUTH I.R.VETTER,C.NOWAK,T.NISHIMOTO,J.KUHLMANN,AUTH 2 A.WITTINGHOFERTITL STRUCTURE OF A RAN-BINDING DOMAIN COMPLEXED WITHTITL 2 RAN BOUND TO A GTP ANALOGUE: IMPLICATIONS FORTITL 3 NUCLEAR TRANSPORT.REF NATURE V. 398 39 1999REFN ISSN 0028-0836PMID 10078529DOI 10.1038/17969 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3qs7 FLT3LG crystal structure of a human flt3 ligand-receptor ternary complex 4.3Å AUTH K.VERSTRAETE,G.VANDRIESSCHE,M.JANUAR,J.ELEGHEERT,AUTH 2 A.V.SHKUMATOV,A.DESFOSSES,K.VAN CRAENENBROECK,D.I.SVERGUN,AUTH 3 I.GUTSCHE,B.VERGAUWEN,S.N.SAVVIDESTITL STRUCTURAL INSIGHTS INTO THE EXTRACELLULAR ASSEMBLY OF THETITL 2 HEMATOPOIETIC FLT3 SIGNALING COMPLEX.REF BLOOD V. 118 60 2011REFN ISSN 0006-4971PMID 21389326DOI 10.1182/BLOOD-2011-01-329532 Variant Set Distributions Mapped Variants
General Structure Information 3l2p LIG3 human dna ligase iii recognizes dna ends by dynamic switching between two dna bound states 3.0Å AUTH E.COTNER-GOHARA,I.K.KIM,M.HAMMEL,J.A.TAINER,A.E.TOMKINSON,AUTH 2 T.ELLENBERGERTITL HUMAN DNA LIGASE III RECOGNIZES DNA ENDS BY DYNAMICTITL 2 SWITCHING BETWEEN TWO DNA-BOUND STATES.REF BIOCHEMISTRY V. 49 6165 2010REFN ISSN 0006-2960PMID 20518483DOI 10.1021/BI100503W Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3mx0 EFNA5 crystal structure of epha2 ectodomain in complex with ephrin-a5 3.51Å AUTH J.P.HIMANEN,L.YERMEKBAYEVA,P.W.JANES,J.R.WALKER,K.XU,AUTH 2 L.ATAPATTU,K.R.RAJASHANKAR,A.MENSINGA,M.LACKMANN,AUTH 3 D.B.NIKOLOV,S.DHE-PAGANONTITL ARCHITECTURE OF EPH RECEPTOR CLUSTERS.REF PROC.NATL.ACAD.SCI.USA V. 107 10860 2010REFN ISSN 0027-8424PMID 20505120DOI 10.1073/PNAS.1004148107 Variant Set Distributions Mapped Variants
General Structure Information 1ihi AKR1C2 crystal structure of human type iii 3-alpha-hydroxysteroid dehydrogenase/bile acid binding protein (akr1c2) complexed with nadp+ and ursodeoxycholate 3.0Å AUTH Y.JIN,S.E.STAYROOK,R.H.ALBERT,N.T.PALACKAL,AUTH 2 T.M.PENNING,M.LEWISTITL CRYSTAL STRUCTURE OF HUMAN TYPE IIITITL 2 3ALPHA-HYDROXYSTEROID DEHYDROGENASE/BILE ACIDTITL 3 BINDING PROTEIN COMPLEXED WITH NADP(+) ANDTITL 4 URSODEOXYCHOLATE.REF BIOCHEMISTRY V. 40 10161 2001REFN ISSN 0006-2960PMID 11513593DOI 10.1021/BI010919A […]