General Structure Information
| PDB ID | 3pjc |
| HGNC Gene Label(s) | JAK3 |
| Structure Name | crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family |
| Resolution | 2.2Å |
| Reference | AUTH G.THOMA,F.NUNINGER,R.FALCHETTO,E.HERMES,G.A.TAVARES,AUTH 2 E.VANGREVELINGHE,H.G.ZERWESTITL IDENTIFICATION OF A POTENT JANUS KINASE 3 INHIBITOR WITHTITL 2 HIGH SELECTIVITY WITHIN THE JANUS KINASE FAMILY.REF J.MED.CHEM. V. 54 284 2011REFN ISSN 0022-2623PMID 21155605DOI 10.1021/JM101157Q |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 286 |
| Number Of SNVs | 53 |
| Number Of Permutations | 28067 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.189 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 286 |
| Number Of SNVs | 5 |
| Number Of Permutations | 341 |
| Optimal Distance Threshold | 24.0 |
| K Statistic | 0.2 |
| p-value | 0.251 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | -0.264 |
| p-value | 0.256 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
