General Structure Information
| PDB ID | 2zks |
| HGNC Gene Label(s) | GZMM |
| Structure Name | structural insights into the proteolytic machinery of apoptosis- inducing granzyme m |
| Resolution | 2.7Å |
| Reference | AUTH L.WU,L.WANG,G.HUA,K.LIU,X.YANG,Y.ZHAI,M.BARTLAM,F.SUN,Z.FANTITL STRUCTURAL BASIS FOR PROTEOLYTIC SPECIFICITY OF THE HUMANTITL 2 APOPTOSIS-INDUCING GRANZYME MREF J.IMMUNOL. V. 183 421 2009REFN ISSN 0022-1767PMID 19542453DOI 10.4049/JIMMUNOL.0803088 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 231 |
| Number Of SNVs | 77 |
| Number Of Permutations | 8242 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.027 |
| p-value | 0.67 |
COSMIC
| Number Of Residues | 231 |
| Number Of SNVs | 3 |
| Number Of Permutations | 66 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.645 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 77 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.234 |
| p-value | 0.969 |